Targeting epigenetics as future treatments of trauma- and stress-or-related disorders. Epidrugs and epinutraceuticals

Inflammatory Thyroid Changes Following Serotonin Receptor Blocking in Experimental Rats

“…Most clinical studies of cognitive enhancers in patients with psychiatric disorders have emphasized medicines that target the hypothalamic-pituitaryadrenal axis. 4 As indicated in research, clinical and subclinical hypothyroidism is common in patients with resistant depression, with a prevalence of approximately 20%. Given the interrelationship between hypothyroidism and depression, and the cognitive consequences, thyroid hormones may improve cognitive function in both disorders.…”

“…Given the interrelationship between hypothyroidism and depression, and the cognitive consequences, thyroid hormones may improve cognitive function in both disorders. 5,6 Due to a lack of research, data on the effect of thyroid abnormalities on cognitive performance in patients with bipolar disorder and major depressive disorder are scarce.…”

Pathophysiological Electrolyte Changes Connoted via Antagonism of Serotonin Receptor in Experimental Animals

“…1 However, the remarkable success of this new class of drugs was soon followed by reports of adverse events, including unanticipated medical events that could occur at any dose and were temporarily related to, but not necessarily causally related to, the use of the drug product, particularly severe extrapyramidal symptoms in subjects, including opioids, seizures, involuntary movements, muscle spasms, and delayed side effects such as Parkinson's disease or delayed onset of abnormal excretion. [2][3][4] There have also been cases of fatal neuroleptic malignant syndrome characterized by joint and muscle stiffness, fever, and elevated plasma creatine kinase activity. The most common adverse reactions and side effects are unintended consequences of the pharmacological properties of the drug occurring at normal doses and include sedation, cardiovascular effects (including hypotension) and sexual dysfunction (e.g., ejaculatory dysfunction, erectile dysfunction, and others).…”

“…5 Anticholinergic side effects (e.g., constipation, urinary retention, dry mouth, blurred vision, and cognitive impairment), seizures, severe blood problems, weight gain and hyperprolactinemia. 4 Namely. Hypotension, prolonged ventricular repolarization, arrhythmias, and sudden cardiac death.…”