2023
DOI: 10.1053/j.akdh.2022.12.003
|View full text |Cite
|
Sign up to set email alerts
|

Targeting Glomerular Hemodynamics for Kidney Protection

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

0
4
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 8 publications
(4 citation statements)
references
References 100 publications
0
4
0
Order By: Relevance
“…We should no longer be fatalistic bystanders but should become active drivers of therapeutic approaches. The possibility of effectively targeting renal hemodynamics and metabolism and the commercial interest in marketing these therapies are pushing not only to develop better benchmarks, but also to improve the understanding of progression of kidney disease [26]. The need to individualize therapies with pathophysiology-based use of, for example, renin-angiotensin system, and SGLT2-inhibitors, GLP1 and mineralocorticoid receptor antagonists requires accurate measurement of GFR and understanding of the dynamics in response to these therapies, hence the RFR [27].…”
Section: Why Is the Renal Functional Reserve Important?mentioning
confidence: 99%
See 1 more Smart Citation
“…We should no longer be fatalistic bystanders but should become active drivers of therapeutic approaches. The possibility of effectively targeting renal hemodynamics and metabolism and the commercial interest in marketing these therapies are pushing not only to develop better benchmarks, but also to improve the understanding of progression of kidney disease [26]. The need to individualize therapies with pathophysiology-based use of, for example, renin-angiotensin system, and SGLT2-inhibitors, GLP1 and mineralocorticoid receptor antagonists requires accurate measurement of GFR and understanding of the dynamics in response to these therapies, hence the RFR [27].…”
Section: Why Is the Renal Functional Reserve Important?mentioning
confidence: 99%
“…Furthermore, measurement of RFR may create opportunities for more evidence-based individualization of therapies in diverse settings [ 6 ▪▪ ]. Given the game-changing potential of the sodium-glucose-cotransporter 2 (SGLT2)-inhibitors, in patients whose creatinine levels rise significantly after treatment initiation for example, knowledge of an individual's RFR over time may enhance personalization of therapy, and may provide confidence to continue therapy in patients in whom this may otherwise have been stopped out of ‘caution’ [ 6 ▪▪ , 26 ].…”
Section: Potential Utility Of Renal Functional Reserve Measurementsmentioning
confidence: 99%
“…Recent studies have identified a reduction in the rate of decline of renal function in patients treated with some SGLT2 inhibitors. 7,[11][12][13][14] 2 | METHODS…”
Section: Introductionmentioning
confidence: 99%
“…The effects of bexagliflozin in the Stage 3 CKD population are significant because renal failure is one of the more severe consequences of T2DM and is a major medical and socio‐economic burden to society. Recent studies have identified a reduction in the rate of decline of renal function in patients treated with some SGLT2 inhibitors 7,11–14 …”
Section: Introductionmentioning
confidence: 99%