Targeting glypicans through EGFR and JAK/STAT signaling axes drives breast cancer progression
Paraskevi Ioannou,
Kyriaki Tzaferi,
Christos Koutsakis
et al.
Abstract:Extracellular matrix (ECM) and its dynamic remodeling contribute to the progression of breast cancer, the most prevailing cancer type in women. Glypicans (GPCs) function as cell co‐receptors by facilitating the formation of ligand–receptor complexes. An important regulator in the context of breast cancer progression is the JAK/STAT signaling pathway that oversees the expression of genes associated with cancer cell characteristics. Epidermal growth factor receptor (EGFR) is a pivotal player in this process. The… Show more
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