Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage
Victoria Jiménez Carretero,
Iris Álvarez-Merz,
Jorge Hernández-Campano
et al.
Abstract:The involvement of the excitatory amino acids glutamate and aspartate in cerebral ischemia and excitotoxicity is well-documented. Nevertheless, the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely understudied. The release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the penumbra. Our findings indicated that the reversible loss of field excitatory postsynaptic potentials caused by transient hypoxia became irreversi… Show more
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