2023
DOI: 10.3390/molecules28073103
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Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach

Abstract: Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host’s immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to prevent its progression, HIV-1 remains a major burden on health resources worldwide. Continued emergence of drug-resistance mutations drives the need for novel drugs that can inhibit HIV-1 replication through new pathways. The viral protein reverse transcriptase (RT) plays a fundamental role in the HI… Show more

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Cited by 4 publications
(1 citation statement)
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“…HIV exhibits high genetic variability and rapid mutation, enabling escape from host immune responses and antiviral drugs. The latent HIV reservoir formed early in resting memory CD4 T cells is a major barrier to curing infection [8]. Since its emergence, HIV/AIDS has caused over 36 million deaths globally [9].…”
Section: Introductionmentioning
confidence: 99%
“…HIV exhibits high genetic variability and rapid mutation, enabling escape from host immune responses and antiviral drugs. The latent HIV reservoir formed early in resting memory CD4 T cells is a major barrier to curing infection [8]. Since its emergence, HIV/AIDS has caused over 36 million deaths globally [9].…”
Section: Introductionmentioning
confidence: 99%