Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment?

Liang, Bing; Deng, Lin; Zhou, Xiaofeng

doi:10.1016/j.biopha.2022.113917

Biomedicine & Pharmacotherapy

2022

DOI: 10.1016/j.biopha.2022.113917

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Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment?

Bing Liang¹,

Lin Deng²,

Xiaofeng Zhou³

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2024

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Cited by 2 publications

References 161 publications

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Motor‐Cargo Structured Nanotractors for Augmented NIR Phototherapy via Gas‐Boosted Tumor Penetration and Respiration‐Impaired Mitochondrial Dysfunction

Wang,

Zhang,

Chen

et al. 2024

Adv Healthcare Materials

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Tumor microenvironment, characterized by dense extracellular matrix and severe hypoxia, has caused pronounced resistance to photodynamic therapy (PDT). Herein, it has designed an artificial nitric oxide (NO) nanotractor with a unique “motor‐cargo” structure, where a photoswitching upconversion nanoparticle (UCNP) core serves as the optical engine to harvest NIR light and asymmetrically coated mesoporous silica (SiO2) shell acts as a cargo unit to load nitric oxide (NO) fuel molecule (RBS, Roussin's black salt) and PDT photosensitizer (ZnPc, zinc phthalocyanine). Upon illumination by 980 nm light, the UCNP emits blue light to excite RBS salt and release NO gas. On one hand, NO is used as the driving force to propel the particle with a high speed of ≈194 µm s−1 that generates significant rupture stress (over 0.95 kPa) on cell membrane to promote cellular endocytosis and intratumoral penetration. On the other hand, NO enables to alleviate tumor hypoxia by inhibiting cellular respiration as an oxygen conserver. When the excitation is subsequently switched to 808 nm light, the UCNP emits red light, triggering ZnPc to produce large amount of reactive oxygen species for PDT treatment. This study explores Janus‐typed nanostructures for cell‐particle interaction and gas‐assisted phototherapy, opening avenues for versatile bioapplications.

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Motor‐Cargo Structured Nanotractors for Augmented NIR Phototherapy via Gas‐Boosted Tumor Penetration and Respiration‐Impaired Mitochondrial Dysfunction

Wang,

Zhang,

Chen

et al. 2024

Adv Healthcare Materials

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The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1α in Vascular Calcification

Zhang,

Wang,

et al. 2024

Biomolecules

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HIF-1α plays a crucial regulatory role in vascular calcification (VC), primarily influencing the osteogenic differentiation of VSMCs through oxygen-sensing mechanisms. Under hypoxic conditions, the stability of HIF-1α increases, avoiding PHD and VHL protein-mediated degradation, which promotes its accumulation in cells and then activates gene expressions related to calcification. Additionally, HIF-1α modulates the metabolic state of VSMCs by regulating the pathways that govern the switch between glycolysis and oxidative phosphorylation, thereby further advancing the calcification process. The interaction between HIF-1α and other signaling pathways, such as nuclear factor-κB, Notch, and Wnt/β-catenin, creates a complex regulatory network that serves as a critical driving force in VC. Therefore, a deeper understanding of the role and regulatory mechanism of the HIF-1α signaling during the development and progression of VC is of great significance, as it is not only a key molecular marker for understanding the pathological mechanisms of VC but also represents a promising target for future anti-calcification therapies.

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Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment?

Cited by 2 publications

References 161 publications

Motor‐Cargo Structured Nanotractors for Augmented NIR Phototherapy via Gas‐Boosted Tumor Penetration and Respiration‐Impaired Mitochondrial Dysfunction

Motor‐Cargo Structured Nanotractors for Augmented NIR Phototherapy via Gas‐Boosted Tumor Penetration and Respiration‐Impaired Mitochondrial Dysfunction

The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1α in Vascular Calcification

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