TargetingMycobacterium tuberculosisiron-scavenging tools: a recent update on siderophores inhibitors

Abstract

Mycobacterium tuberculosis siderophores inhibitors.

Synthesis and Analytical Characterization of Cyclization Products of 3-Propargyloxy-5-benzyloxy-benzoic Acid Methyl Ester

“…As part of a project focusing on the design and synthesis of new inhibitors of the salicylate synthase MbtI from M. tuberculosis [19][20][21][22][23][24][25][26], we investigated several heterocyclic cores [27][28][29][30], including the chroman-4-one and chromane scaffolds [31,32]. Our studies led to the synthesis of a pool of derivatives, which were tested for their inhibitory effect towards this target, demonstrating promising activities [31,32].…”

Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery

“…The formation of the terminal chain is mediated by MbtL, MbtM, and MbtN, while its fusion to the core scaffold is catalyzed by MbtK [3]. Because they act upstream in the biosynthetic pathway, MbtI and MbtA have been widely investigated as potential targets for anti-virulence therapeutic strategies against tuberculosis (TB) [6,[28][29][30]. Studies on these two enzymes have led to numerous potent inhibitors, with promising antimycobacterial activities both on isolated strains and infected macrophage models [31][32][33][34][35][36][37][38][39][40][41][42].…”