Targeting immunosenescence for improved tumor immunotherapy
Zaoqu Liu,
Lulu Zuo,
Zhaokai Zhou
et al.
Abstract:Tumor immunotherapy has significantly transformed the field of oncology over the past decade. An optimal tumor immunotherapy would ideally elicit robust innate and adaptive immune responses within tumor immune microenvironment (TIME). Unfortunately, immune system experiences functional decline with chronological age, a process termed “immunosenescence,” which contributes to impaired immune responses against pathogens, suboptimal vaccination outcomes, and heightened vulnerability to various diseases, including … Show more
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