Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review

Kioussis, Benjamin; Tuttle, Camilla; Heard, Daniel S.; Kennedy, Brian K.; Lautenschlager, Nicola T.; Maier, Andrea B.

doi:10.1016/j.arr.2021.101302

Cited by 15 publications

(9 citation statements)

References 192 publications

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“…Cognitive ability is the capacity of the human brain to process, store and extract information ( Hunter, 1986 ). Cognitive decline is a progressive neurodegenerative disease associated with increasing age among the elderly ( Li et al, 2019 ; Kioussis et al, 2021 ; Liu et al, 2021 ). The aggravation of cognitive decline is likely to lead to Alzheimer’s disease, dementia, and death ( Backman et al, 2005 ; Prince et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal associations between sleep duration and cognitive impairment in Chinese elderly

Chen

Wang

2022

Front. Aging Neurosci.

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BackgroundAge-associated cognitive decline has become a major threat to both personal welfare and public health and can further develop into Dementia/Alzheimer’s disease. Sleep is significantly correlated with cognitive function, but both cognitive impairment and sleep problems increase with normal aging. This study explored how sleep duration affects cognitive performance among older adults in China.MethodsUsing data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2014 and 2018, cognitive function was assessed via the Mini-Mental State Examination (MMSE), which included five domains: orientation, registration, attention or calculation, recall, and language. Logistic regression was used to examine whether the change in sleep duration was a risk factor for cognitive impairment. We also used multinomial logistic regression to study the impact of sleep duration and the changes in sleep duration on cognitive changes during the follow-up period.ResultsThe empirical study showed a U-shaped relationship between sleep duration and increased risk of cognitive impairment. Short (< 6 hours) and long (> 8 hours) sleep durations were positively associated with cognitive impairment. Tests of interactions between sleep duration and sleep quality showed that short sleep durations with fair sleep quality had an increased risk of cognitive impairment. Further, the participants were divided into three groups: normal cognition (MMSE > 24), mild cognitive impairment (MCI, 18 ≤ MMSE score ≤ 24), and severe cognitive impairment (MMSE < 18). First, of the participants with normal cognition at baseline, those who sleeping > 7 h at follow-up and > 7 h at both baseline and 4-year follow-up assessments could increase the risk of cognitive impairment. Second, for individuals with MCI at baseline, those who transitioned to sleeping > 7 h at follow-up period and > 7 h at both baseline and 4-year follow-up assessments had a lower chance of reverting to normal cognition.ConclusionExcessive sleep may be a major risk for cognitive impairment among older adults. Furthermore, a moderate amount of sleep could be a possible strategy to prevent cognitive impairment.

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Section: Introductionmentioning

confidence: 99%

Longitudinal associations between sleep duration and cognitive impairment in Chinese elderly

Chen

Wang

2022

Front. Aging Neurosci.

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“…mTORC1 is one of the most studied amino acid nutrient sensing signaling pathwys and plays a key role in both Aβ and TAU pathologies. Aβ accumulation has been associated to the overactivation of mTORC1 signaling, whilst mTOR signaling inhibition leads to reduced Aβ levels ( Caccamo et al, 2010 ; Kioussis et al, 2021 ). Moreover, accumulating evidence suggests that mTOR activation enhances TAU pathology via autophagy inhibition which, in turn, enhances Aβ accumulation ( Tramutola et al, 2017 ), that further promotes TAU hyperphosphorylation.…”

Section: Defects Of Nutrient Signaling and Autophagy In Alzheimer’s D...mentioning

confidence: 99%

Defects of Nutrient Signaling and Autophagy in Neurodegeneration

Ondaro

Hernandez-Eguiazu

Garciandia-Arcelus

et al. 2022

Front. Cell Dev. Biol.

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“…Andrea Maier, National University of Singapore, Singapore, stressed the need for an unbiased standardized characterization and reporting of research outcome in the form of a minimum required dataset and trial networks to combat the poor transition currently seen. Additionally, she suggested drug repurposing as a relatively cheap and faster way for new age-related treatments [59,60]. The great benefit of drug repurposing was also highlighted by Nir Barzilai, Albert Einstein College of Medicine, USA, who studies the repurposing of FDA approved drugs such as metformin and canagliflozin [61].…”

Section: Agingmentioning

confidence: 99%

Meeting Report: Aging Research and Drug Discovery

Meron

Thaysen

Angeli

et al. 2022

Aging

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Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is expanding alongside a growing focus from the industry and investors in aging research. This year's 8th Annual Aging Research and Drug Discovery (ARDD) meeting was organized as a hybrid meeting from August 30th to September 3rd 2021 with more than 130 attendees participating on-site at the Ceremonial Hall at University of Copenhagen, Denmark, and 1800 engaging online. The conference comprised of presentations from 75 speakers focusing on new research in topics including mechanisms of aging and how these can be modulated as well as the use of AI and new standards of practices within aging research. This year, a longevity workshop was included to build stronger connections with the clinical community.

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Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review

Cited by 15 publications

References 192 publications

Longitudinal associations between sleep duration and cognitive impairment in Chinese elderly

Longitudinal associations between sleep duration and cognitive impairment in Chinese elderly

Defects of Nutrient Signaling and Autophagy in Neurodegeneration

Meeting Report: Aging Research and Drug Discovery

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