Targeting inflammation in traumatic injury: entering a new era

Billiar, Timothy R.; Hunt, Beverley J.; Bailly, Sébastien

doi:10.1007/s00134-023-07152-2

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…Trauma is becoming the most common factor related to mortality in individuals aged < 45 years in China, which has induced a substantial burden on both the individuals and their families [ 5 , 6 ]. For patients, trauma can result in immediate death or serious complications, like hemorrhagic shock, systemic inflammatory response, and multiple organ dysfunction syndrome that require rapidly diagnosis and treatment in intensive care unit (ICU) [ 7 – 9 ]. For families, treating trauma patients in the ICU is an unanticipated and devastating event, as their healthy loved ones abruptly enter a state of urgent critical illness with a higher risk of death and disability, so they are often not well prepared to confront with trauma-related challenges, which may thereby induce psychological distress like depression, anxiety, and illness uncertainty [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Psychological resilience in the relationship between family function and illness uncertainty among family members of trauma patients in the intensive care unit

Yu,

Zhang,

et al. 2024

BMC Psychiatry

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Background Severe trauma accounts for a main factor inducing mortality for individuals aged < 45 years in China, which requires admission to intensive care unit (ICU) to receive comprehensive treatment. Family members of patients with unanticipated and life-threatening trauma during their ICU stays often experience psychosocial distress due to illness uncertainty. Previous research has shown that family function and psychological resilience are associated with illness uncertainty, respectively. However, little is known about the current situation and interacting mechanism between family function, psychological resilience, and illness uncertainty of family members for ICU trauma patients. Therefore, this study focused on exploring the current situation and relationships between these three factors in family members for ICU trauma patients. Methods The convenience sampling approach was adopted in the present cross-sectional survey, which involved 230 family members for ICU trauma patients from 34 hospitals in Chongqing, China. Related data were extracted with self-reporting questionnaires, which included sociodemographic characteristic questionnaire, the Family Adaptability, Partnership, Growth, Affection and Resolve Scale (APGAR), the 10-item Connor-Davidson Resilience Scale (10-CD-RISC) and the Mishel’s Illness Uncertainty Scale for Family Members (MUIS-FM). Pearson correlation analysis was conducted to examine the correlations between various variables. Additionally, a structural equation model was adopted to assess the mediating effect of psychological resilience on family function and illness uncertainty. Results According to our results, family members for ICU trauma patients experienced high illness uncertainty with moderate family dysfunction and low psychological resilience. Family function directly affected illness uncertainty and indirectly affected illness uncertainty through psychological resilience in family members of ICU trauma patients. Conclusions Family function and psychological resilience are the protective factors for reducing illness uncertainty. Healthcare providers should take effective measures, including family-functioning improvement and resilience-focused interventions, for alleviating illness uncertainty in family members of ICU trauma patients.

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Section: Introductionmentioning

confidence: 99%

Psychological resilience in the relationship between family function and illness uncertainty among family members of trauma patients in the intensive care unit

Yu,

Zhang,

et al. 2024

BMC Psychiatry

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CD4 + T cells ferroptosis is associated with the development of sepsis in severe polytrauma patients

Kong,

Cai,

Xie

et al. 2024

International Immunopharmacology

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Does Scheduled Low-Dose Short-Term NSAID (Ketorolac) Modulate Cytokine Levels Following Orthopaedic Polytrauma? A Secondary Analysis of a Randomized Clinical Trial

Foster,

Hawk,

Landy

et al. 2024

Journal of Orthopaedic Trauma

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OBJECTIVES: To determine whether scheduled low-dose, short-term ketorolac modulates cytokine concentrations in orthopaedic polytrauma patients. METHODS: Design: Secondary analysis of a double-blinded, randomized controlled trial. Setting: Single Level I trauma center from August 2018 to October 2022. Patient Selection Criteria: Orthopaedic polytrauma patients between 18-75 years with a New Injury Severity Score greater than 9 were enrolled. Participants were randomized to receive 15 mg of intravenous (IV) ketorolac every 6 hours for up to 5 inpatient days or 2 mL of IV saline similarly. Outcome Measures and Comparisons: Daily concentrations of prostaglandin E2 (PGE2), interleukin (IL)-1a, IL-1b, IL-6, and IL-10. Clinical outcomes included hospital and intensive care unit (ICU) length of stay (LOS), pulmonary complications, and acute kidney injury (AKI). RESULTS: Seventy orthopaedic polytrauma patients were enrolled, with 35 participants randomized to the ketorolac group and 35 to the placebo group. The overall IL-10 trend over time was significantly different in the ketorolac group (p = 0.043). IL-6 was 65.8% higher at enrollment compared to Day 3 (p < 0.001) when aggregated over both groups. There was no significant treatment effect for PGE2, IL-1a, or IL-1b (p > 0.05). There were no significant differences in clinical outcomes between groups (p > 0.05). CONCLUSIONS: Scheduled low-dose, short-term, IV ketorolac was associated with significantly different mean trends in IL-10 concentration in orthopaedic polytrauma patients with no significant differences in PGE2, IL-1a, IL-1b, or IL-6 levels between groups. The treatment did not have an impact on clinical outcomes of hospital or ICU LOS, pulmonary complications, or AKI. LEVEL OF EVIDENCE: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.

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Targeting inflammation in traumatic injury: entering a new era

Cited by 4 publications

References 13 publications

Psychological resilience in the relationship between family function and illness uncertainty among family members of trauma patients in the intensive care unit

Psychological resilience in the relationship between family function and illness uncertainty among family members of trauma patients in the intensive care unit

CD4 + T cells ferroptosis is associated with the development of sepsis in severe polytrauma patients

Does Scheduled Low-Dose Short-Term NSAID (Ketorolac) Modulate Cytokine Levels Following Orthopaedic Polytrauma? A Secondary Analysis of a Randomized Clinical Trial

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