Targeting kelch-like (KLHL) proteins: achievements, challenges and perspectives

Zhou, Yangguo; Zhang, Qiong; Zhao, Ziquan; Hu, Xiuqi; You, Qidong; Jiang, Zhengyu

doi:10.1016/j.ejmech.2024.116270

European Journal of Medicinal Chemistry

2024

DOI: 10.1016/j.ejmech.2024.116270

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Targeting kelch-like (KLHL) proteins: achievements, challenges and perspectives

Yangguo Zhou,

Qiong Zhang,

Ziquan Zhao

et al.

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2024

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Allelic effects onKLHL17expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33

Connelly,

Hullin,

Abdolalizadeh

et al. 2024

Preprint

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Pancreatic Ductal Adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the U.S. Both rare and common germline variants contribute to PDAC risk. Here, we fine-map and functionally characterize a common PDAC risk signal at 1p36.33 (tagged by rs13303010) identified through a genome wide association study (GWAS). One of the fine-mapped SNPs, rs13303160 (r2=0.93 in 1000G EUR samples, OR=1.23,Pvalue=2.74×10−9) demonstrated allele-preferential gene regulatory activityin vitroand allele-preferential binding of JunB and JunDin vitroandin vivo. Expression Quantitative Trait Locus (eQTL) analysis identifiedKLHL17as a likely target gene underlying the signal. Proteomic analysis identified KLHL17 as a member of the Cullin-E3 ubiquitin ligase complex in PDAC-derived cells.In silicodifferential gene expression analysis of the GTExv8 pancreas data suggested an association between lower KLHL17 (risk associated) and pro-inflammatory pathways. We hypothesize that KLHL17 may mitigate inflammation by recruiting pro-inflammatory proteins for ubiquitination and degradation thereby influencing PDAC risk.

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Allelic effects onKLHL17expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33

Connelly,

Hullin,

Abdolalizadeh

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Targeting kelch-like (KLHL) proteins: achievements, challenges and perspectives

Cited by 1 publication

References 271 publications

Allelic effects onKLHL17expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33

Allelic effects onKLHL17expression likely mediated by JunB/D underlie a PDAC GWAS signal at chr1p36.33

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