2019
DOI: 10.1016/j.tibs.2019.01.001
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Targeting Metabolic–Redox Circuits for Cancer Therapy

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Cited by 138 publications
(139 citation statements)
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References 78 publications
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“…In this regard, the concomitant inhibition of antioxidant circuits and metabolic pathways that support the redox balance of malignant cells, delineates a promising anti-cancer strategy [274][275][276][277][278][279][280][281][282][283]. It is known that most of the metabolic changes promoting cancer cells proliferation and tumor growth induce also an increased ROS generation, counterbalanced by an antioxidant response that prevents cell death [234,284,285]. Of note, since the cytotoxicity of conventional anti-cancer therapies largely relies on efficient ROS accumulation, the augmented antioxidant capacity of cancer cells constitutes a key determinant of therapy-resistance [286][287][288].…”
Section: Strategies To Negatively Modulate Nrf2 Signaling/pathwaymentioning
confidence: 99%
“…In this regard, the concomitant inhibition of antioxidant circuits and metabolic pathways that support the redox balance of malignant cells, delineates a promising anti-cancer strategy [274][275][276][277][278][279][280][281][282][283]. It is known that most of the metabolic changes promoting cancer cells proliferation and tumor growth induce also an increased ROS generation, counterbalanced by an antioxidant response that prevents cell death [234,284,285]. Of note, since the cytotoxicity of conventional anti-cancer therapies largely relies on efficient ROS accumulation, the augmented antioxidant capacity of cancer cells constitutes a key determinant of therapy-resistance [286][287][288].…”
Section: Strategies To Negatively Modulate Nrf2 Signaling/pathwaymentioning
confidence: 99%
“…ROS are a major class of DNA-damaging agents and play very important roles in suppressing cancer initiation and progression [25,26,[57][58][59][60]. Owing to dysregulated proliferation, cancer cells exhibit abnormal metabolism and high levels of intrinsic oxidative pressure, leading to their dependence on antioxidant systems and DNA repair for survival [26,[59][60][61][62]. The thioredoxin antioxidant pathway is upregulated in tumors and simultaneous inhibition of the thioredoxin and glutathione antioxidant pathways causes synergistic cancer cell death [26].…”
Section: Coadministration Of Atl and Olaparib Suppresses Tumor Growthmentioning
confidence: 99%
“…Mitochondrial ROS are the byproducts of metabolic processes during which electrons escape from the mitochondrial electron transport chain and then are captured by molecular oxygen to generate superoxide anions (O − 2 ) (5). Mitochondrial ROS exhibit both, a tumor promoting or tumor suppressing roles, depending on their levels and their oxidative potential.…”
Section: Introductionmentioning
confidence: 99%