Targeting molecular mechanisms underlying treatment efficacy and resistance in DIPG: A review of current and future strategies

Bentayebi, Kaoutar; Aked, Rim El; Ezzahidi, Oumaima; Alami, Alae Bekkouri; Louati, Sara; Ouadghiri, Mouna; Aanniz, Tarik; Amzazi, Saaïd; Belyamani, Lahcen; Ibrahimi, Azzedine; Suwan, Keittisak; Hajitou, Amin; Eljaoudi, Rachid

doi:10.1016/j.dscb.2024.100132

Brain Disorders

2024

DOI: 10.1016/j.dscb.2024.100132

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Targeting molecular mechanisms underlying treatment efficacy and resistance in DIPG: A review of current and future strategies

Kaoutar Bentayebi,

Rim El Aked,

Oumaima Ezzahidi

et al.

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Emerging and Biological Concepts in Pediatric High-Grade Gliomas

Yoel,

Adjumain,

Liang

et al. 2024

Cells

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Primary central nervous system tumors are the most frequent solid tumors in children, accounting for over 40% of all childhood brain tumor deaths, specifically high-grade gliomas. Compared with pediatric low-grade gliomas (pLGGs), pediatric high-grade gliomas (pHGGs) have an abysmal survival rate. The WHO CNS classification identifies four subtypes of pHGGs, including Grade 4 Diffuse midline glioma H3K27-altered, Grade 4 Diffuse hemispheric gliomas H3-G34-mutant, Grade 4 pediatric-type high-grade glioma H3-wildtype and IDH-wildtype, and infant-type hemispheric gliomas. In recent years, we have seen promising advancements in treatment strategies for pediatric high-grade gliomas, including immunotherapy, CAR-T cell therapy, and vaccine approaches, which are currently undergoing clinical trials. These therapies are underscored by the integration of molecular features that further stratify HGG subtypes. Herein, we will discuss the molecular features of pediatric high-grade gliomas and the evolving landscape for treating these challenging tumors.

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Emerging and Biological Concepts in Pediatric High-Grade Gliomas

Yoel,

Adjumain,

Liang

et al. 2024

Cells

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Targeting molecular mechanisms underlying treatment efficacy and resistance in DIPG: A review of current and future strategies

Cited by 1 publication

References 72 publications

Emerging and Biological Concepts in Pediatric High-Grade Gliomas

Emerging and Biological Concepts in Pediatric High-Grade Gliomas

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