2012
DOI: 10.1093/rheumatology/kes304
|View full text |Cite
|
Sign up to set email alerts
|

Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

Abstract: Biotherapies have revolutionized the treatment of RA. However, much work is needed to understand all the mechanisms of these biotherapies, and alternatives are needed to circumvent adverse effects and the high cost of these long-lasting treatments. In this article we outline some of the approaches we have used to target monocytes/macrophages as major components of inflammation and bone homeostasis. We also discuss how anti-TNF-α antibodies target monocytes/macrophages in the complex mechanisms contributing to … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

3
149
0
1

Year Published

2014
2014
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 183 publications
(153 citation statements)
references
References 107 publications
3
149
0
1
Order By: Relevance
“…This continuous supply of blood monocytes gives rise to both hope and challenges of treating diseases in which activated macrophages play a central role in chronic inflammation (6).…”
Section: Introductionmentioning
confidence: 99%
“…This continuous supply of blood monocytes gives rise to both hope and challenges of treating diseases in which activated macrophages play a central role in chronic inflammation (6).…”
Section: Introductionmentioning
confidence: 99%
“…During the last 2 decades, TNF has been implicated in numerous diseases such as arthritis, 17 Alzheimer disease, 28 cancer, 29 major depression, 30 septic shock, 31 and inflammatory bowel disease. 32 Therefore, anti-TNF therapy has been used in clinical practice.…”
Section: Discussionmentioning
confidence: 99%
“…32 Therefore, anti-TNF therapy has been used in clinical practice. [17][18][19][20] TNF also plays an essential beneficial role in a variety of physiological functions including immune surveillance, sleep regulation, synaptic scaling, and neurogenesis. [33][34][35][36][37][38] TNF was initially recognized for its ability to kill tumor cells without harming normal cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by joint synovitis, cartilage and bone damage, and extra-articular manifestations [1,2] .…”
Section: Introductionmentioning
confidence: 99%