“…It dampens nitric oxide (NO) production in animal models of acute and chronic inflammation (24,152,162,247,267,600,654,758), the expression of inflammatory cytokines and transcription factors [interleukin (IL)-1, IL-2, IL-6, IL-8, tumor necrosis factor (TNF)-␣, interferon (IFN)-␥, CCL3, CCL4, NF-B] (39, 419), and reactive oxygen species (ROS) production (320, 767). However, in many types of cancer cells, CBD is capable of generating ROS, thereby inducing cytotoxicity or apoptosis and autophagy (478,540,543,547,552,610,862). CBD also improves mithochondrial function and enhances mithochondrial biogenesis in vivo under pathological conditions (327).…”