Targeting neddylation as a novel approach to lung cancer treatment (Review)

Abstract

As a protein that resembles ubiquitin, neural precursor cell expressed developmentally downregulated 8 (NEDD8) takes part in neddylation, which modifies substrates in a manner similar to ubiquitination and alters the activity of target proteins. Neddylation may affect the activity of multiple signaling pathways, have a regulatory role in tumor formation, progression and metastasis, and influence the prognosis of cancer treatment. The present review summarizes the regulatory roles of NEDD8 in the MDM2-p53, NF-κB, PI3K/AKT/mTOR, hypoxia-inducible factor, Hippo and receptor tyrosine kinase signaling pathways, as well as in the development and progression of lung cancer. Contents 1. Introduction 2. NEDD8 in post-translational modifications of proteins 3. Substrates and signaling pathways associated with NEDD8 4. Effects of neddylation on lung cancer 5. Lung cancer treatment targeting neddylation 6. Conclusion