2022
DOI: 10.3390/ph15101297
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Targeting NMDA Receptor Complex in Management of Epilepsy

Abstract: N-methyl-D-aspartate receptors (NMDARs) are widely distributed in the central nervous system (CNS) and play critical roles in neuronal excitability in the CNS. Both clinical and preclinical studies have revealed that the abnormal expression or function of these receptors can underlie the pathophysiology of seizure disorders and epilepsy. Accordingly, NMDAR modulators have been shown to exert anticonvulsive effects in various preclinical models of seizures, as well as in patients with epilepsy. In this review, … Show more

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Cited by 20 publications
(13 citation statements)
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“…Further studies on the mechanism of the seizure-attenuating activity of MSO will have to account for its glutamine synthetase inhibition-bypassing effects, including modulation of amino acid transport and metabolism. 34 Glu acting at N-methyl-D-aspartate and αamino-3hydroxy-5-methyl-4-isoxazolepropionic acid receptors, the two receptor classes whose role in epileptogenesis has been widely recognized, 35 mediates Tau release in brain. 36 It appeared reasonable to assume that Tau release observed during the initial seizures may be due to activation of Glu receptors by excessive extrasynaptic accumulation of Glu.…”
Section: Discussionmentioning
confidence: 99%
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“…Further studies on the mechanism of the seizure-attenuating activity of MSO will have to account for its glutamine synthetase inhibition-bypassing effects, including modulation of amino acid transport and metabolism. 34 Glu acting at N-methyl-D-aspartate and αamino-3hydroxy-5-methyl-4-isoxazolepropionic acid receptors, the two receptor classes whose role in epileptogenesis has been widely recognized, 35 mediates Tau release in brain. 36 It appeared reasonable to assume that Tau release observed during the initial seizures may be due to activation of Glu receptors by excessive extrasynaptic accumulation of Glu.…”
Section: Discussionmentioning
confidence: 99%
“…Glu acting at N‐methyl‐D‐aspartate and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptors, the two receptor classes whose role in epileptogenesis has been widely recognized, 35 mediates Tau release in brain 36 . It appeared reasonable to assume that Tau release observed during the initial seizures may be due to activation of Glu receptors by excessive extrasynaptic accumulation of Glu.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, there are other strategies to antagonize NMDARs. These include the use of drugs such as amantadine, magnesium sulfate, remacemide, and MK-801 in epilepsy [77]. These examples illustrate that some NMDAR blockers can reduce seizure frequency and severity in some patients or animal models with refractory epilepsy or GRIN mutations.…”
Section: Nmdar As a Therapeutic Target In Epilepsymentioning
confidence: 99%
“…These examples illustrate that some NMDAR blockers can reduce seizure frequency and severity in some patients or animal models with refractory epilepsy or GRIN mutations. However, the mechanisms of action, efficacy, safety, and optimal dosing of these drugs for epilepsy are still unclear and need further investigation [77].…”
Section: Nmdar As a Therapeutic Target In Epilepsymentioning
confidence: 99%
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