Targeting Non-Coding RNA for CNS Injuries: Regulation of Blood-Brain Barrier Functions

Zhang, Li; Bai, Wanshan; Sun, Lean; Lin, Yingyan; Tian, Mi

doi:10.1007/s11064-023-03892-1

Cited by 8 publications

(8 citation statements)

References 141 publications

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“…MMP-9 is a primary proteolytic enzyme that degrades TJ and AJ proteins. 10 We then examined the expression of MMP-9 after TBI. We found that TBI increased the expression of MMP-9, which was significantly inhibited by fucoxanthin ( Figure 2 D).…”

Section: Resultsmentioning

confidence: 99%

“… 26 TJ proteins are responsible for closing the intercellular cleft, thus preventing free exchange between the CNS and vasculature. 10 AJs are located at the basolateral part of paracellular space and compose of cadherin, integrin and their associated proteins. 27 VE-cadherin as an AJ protein can regulate TJ adhesion and stability, thus contributing to the maintenance of TJ organization.…”

Section: Discussionmentioning

confidence: 99%

“… 9 The damage of BBB after TBI may lead to neurodegenerative and neurological deficits in the brain. 10 , 11 Therefore, repairing of BBB can be the effective therapeutic method for the treatment of TBI.…”

Section: Introductionmentioning

confidence: 99%

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Fucoxanthin ameliorates traumatic brain injury by suppressing the blood–brain barrier disruption

Zhang,

Hu,

Bai

et al. 2023

iScience

Self Cite

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Fucoxanthin ameliorates traumatic brain injury by suppressing the blood–brain barrier disruption

Zhang,

Hu,

Bai

et al. 2023

iScience

Self Cite

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“…Research evaluating the molecular mechanisms linking lncRNAs and the (patho)physiology of brain insults, such as stroke and traumatic brain injury (TBI), has only been recently instigated (Ref. 44). In this regard, Cheng et al were the first to elucidate the pro-neuroinflammatory actions of HOTAIR in TBI.…”

Section: Traumatic Hypoxic and Ischaemic Brain Injurymentioning

confidence: 99%

The multifaceted functions of long non-coding RNAHOTAIRin neuropathologies and its potential as a prognostic marker and therapeutic biotarget

Ahmad,

Sudesh,

Ahmed

et al. 2024

Expert Rev. Mol. Med.

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Long non-coding RNAs (lncRNAs) are progressively being perceived as prominent molecular agents controlling multiple aspects of neuronal (patho)physiology. Amongst these is the HOX transcript antisense intergenic RNA, often abbreviated as HOTAIR. HOTAIR epigenetically regulates its target genes via its interaction with two different chromatin-modifying agents; histone methyltransferase polycomb-repressive complex 2 and histone demethylase lysine-specific demethylase 1. Parenthetically, HOTAIR elicits trans-acting sponging function against multiple micro-RNA species. Oncological research studies have confirmed the pathogenic functions of HOTAIR in multiple cancer types, such as gliomas and proposed it as a pro-oncological lncRNA. In fact, its expression has been suggested to be a predictor of the severity/grade of gliomas, and as a prognostic biomarker. Moreover, a propound influence of HOTAIR in other aspects of brain heath and disease states is just beginning to be unravelled. The objective of this review is to recapitulate all the relevant data pertaining to the regulatory roles of HOTAIR in neuronal (patho)physiology. To this end, we discuss the pathogenic mechanisms of HOTAIR in multiple neuronal diseases, such as neurodegeneration, traumatic brain injury and neuropsychiatric disorders. Finally, we also summarize the results from the studies incriminating HOTAIR in the pathogeneses of gliomas and other brain cancers. Implications of HOTAIR serving as a suitable therapeutic target in neuropathologies are also discussed.

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“…Comprehensive understanding of lncRNAs as mediators of the pathophysiology of brain injuries, such as stroke and TBI, has been initiated only recently (Zhang et al 2023 ). One of the first studies to propose neuroinflammation-stimulating roles of HOTAIR in TBI came from Cheng et al ( 2021 ).…”

Section: Hotair In Non-oncological Brain Pathophysiological ...mentioning

confidence: 99%

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders

Ahmad,

Sudesh,

Ahmed

et al. 2024

Cell Mol Neurobiol

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HOX transcript antisense intergenic RNA (HOTAIR) is a long non-coding RNA (lncRNA) which is increasingly being perceived as a tremendous molecular mediator of brain pathophysiology at multiple levels. Epigenetic regulation of target gene expression carried out by HOTAIR is thorough modulation of chromatin modifiers; histone methyltransferase polycomb repressive complex 2 (PRC2) and histone demethylase lysine-specific demethylase 1 (LSD1). Incidentally, HOTAIR was the first lncRNA shown to elicit sponging of specific microRNA (miRNA or miR) species in a trans-acting manner. It has been extensively studied in various cancers, including gliomas and is regarded as a prominent pro-tumorigenic and pro-oncogenic lncRNA. Indeed, the expression of HOTAIR may serve as glioma grade predictor and prognostic biomarker. The objective of this timely review is not only to outline the multifaceted pathogenic roles of HOTAIR in the development and pathophysiology of gliomas and brain cancers, but also to delineate the research findings implicating it as a critical regulator of overall brain pathophysiology. While the major focus is on neuro-oncology, wherein HOTAIR represents a particularly potent underlying pathogenic player and a suitable therapeutic target, mechanisms underlying the regulatory actions of HOTAIR in neurodegeneration, traumatic, hypoxic and ischemic brain injuries, and neuropsychiatric disorders are also presented. Graphical Abstract HOTAIR-mediated epigenetic DNA regulation and molecular sponging of target miRNAs. While the 5′ end of HOTAIR regulates the H3K27 trimethylation activity of the catalytic subunit enhancer of Zeste homolog 2 (EZH2) of the polycomb repressive complex 2 (PRC2), its 3′ end modulates the H3K4 demethylation activity of lysine-specific demethylase 1 (LSD1). HOTAIR also binds to and competitively inhibits the functions of target miRNAs, altering the expression of downstream genes.

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Targeting Non-Coding RNA for CNS Injuries: Regulation of Blood-Brain Barrier Functions

Cited by 8 publications

References 141 publications

Fucoxanthin ameliorates traumatic brain injury by suppressing the blood–brain barrier disruption

Fucoxanthin ameliorates traumatic brain injury by suppressing the blood–brain barrier disruption

The multifaceted functions of long non-coding RNAHOTAIRin neuropathologies and its potential as a prognostic marker and therapeutic biotarget

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders

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