Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals

Gado, Francesca; Ferrario, Giulio; Vedova, Larissa Della; Zoanni, Beatrice; Altomare, Alessandra; Carini, Marina; Aldini, Giancarlo; D’Amato, Alfonsina; Baron, Giovanna

doi:10.3390/molecules28031356

Cited by 15 publications

(8 citation statements)

References 78 publications

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“…Activation of the NF-κB signaling pathway leads to the upregulation of multiple genes responsible for subsequent inflammation and immune responses. Increasing evidence suggests that the dysregulation of the NF-κB signaling pathway may lead to the development of serious chronic inflammation, autoimmune diseases, and cancer ( 21 - 23 ), and there is also research showing its close relationship with GC ( 24 , 25 ).…”

Section: Discussionmentioning

confidence: 99%

BMP6 inhibits gastric cancer growth and predicts good prognosis

Song,

Liu,

Wang

et al. 2024

J Gastrointest Oncol

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Background Gastric cancer (GC) is a common tumors in the digestive tract, and effective treatment methods are still lacking. Bone morphogenetic protein 6 (BMP6) is closely related to the occurrence and development of various tumors, but its relevance to GC is still unclear. The aim of the study was to explore the relationship between BMP6 and the occurrence and development of GC. Methods In this study, we investigated the relationship between BMP6 and the prognosis of GC patients using bioinformatics technology and clinical tissue samples. We also explored the connection between BMP6 and the biological behavior of GC cells through molecular biology experiments and relevant in vivo animal experiments. Finally, we examined the mechanisms by which BMP6 inhibits the onset and progression of GC. Results Through analysis of The Cancer Genomics Atlas (TCGA) database, we observed that BMP6 is expressed at low levels in GC, and its low expression is associated with a poor prognosis in GC patients. Cell experiments demonstrated that BMP6 expression can influence the proliferation of GC cells both in vitro and in vivo . Furthermore, we discovered that BMP6 is linked to the nuclear factor-κB (NF-κB) pathway, and subsequent experiments confirmed that BMP6 can inhibit the biological activity of GC cells by activating the NF-κB pathway. Conclusions Our findings suggest that BMP6 is a potential prognostic biomarker in GC and can regulate the biological activity of GC cells through the NF-κB pathway. BMP6 may serve as a promising therapeutic target for GC, and our study introduces novel ideas for the prevention and treatment of this disease.

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Section: Discussionmentioning

confidence: 99%

BMP6 inhibits gastric cancer growth and predicts good prognosis

Song,

Liu,

Wang

et al. 2024

J Gastrointest Oncol

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“…Under conditions of moderate oxidative stress, cells activate Nrf2 to maintain redox homeostasis. Nrf2 is known to be a master regulator that controls the transcriptional activation of genes involved in antioxidation, antioxidant biosynthesis and metabolic changes ( Gado et al, 2023 ; Lo and Hannink, 2008 ; Zeb et al, 2021 ). Often, even this protective mechanism fails in the presence of high levels of ROS.…”

Section: Discussionmentioning

confidence: 99%

The polyphenolic compound punicalagin protects skin fibroblasts from UVA radiation oxidative damage

Bianchetti,

Bottoni,

Tringali

et al. 2024

Current Research in Pharmacology and Drug Discovery

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“…In the presence of redox imbalance, the complex on the outer membrane of mitochondria degrades and causes the dissociation of Nrf2. Free Nrf2 enters the nucleus and activates antioxidant and antiapoptotic gene expression to mitigate oxidative mitochondrial stress [ 51 , 52 , 53 ]. In confirmation of this, experimental evidence shows that cells of Nrf2-KO animals are highly sensitive to chemical-induced mitochondrial damage, whereas chemo-preventive agents protect against mitochondrial damage [ 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway

et al. 2023

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This study explores the photoprotective effects of rutin, a bioflavonoid found in some vegetables and fruits, against UVA-induced damage in human skin fibroblasts. Our results show that rutin increases cell viability and reduces the high levels of ROS generated by photo-oxidative stress (1 and 2 h of UVA exposure). These effects are related to rutin’s ability to modulate the Nrf2 transcriptional pathway. Interestingly, activation of the Nrf2 signaling pathway results in an increase in reduced glutathione and Bcl2/Bax ratio, and the subsequent protection of mitochondrial respiratory capacity. These results demonstrate how rutin may play a potentially cytoprotective role against UVA-induced skin damage through a purely antiapoptotic mechanism.

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Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals

Cited by 15 publications

References 78 publications

BMP6 inhibits gastric cancer growth and predicts good prognosis

BMP6 inhibits gastric cancer growth and predicts good prognosis

The polyphenolic compound punicalagin protects skin fibroblasts from UVA radiation oxidative damage

Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway

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