Targeting Nuclear Factor-Kappa B Signaling Pathway by Curcumin: Implications for the Treatment of Multiple Sclerosis

Gachpazan, Meysam; Habbibirad, Sadra; Kashani, Hoda; Jamialahmadi, Tannaz; Rahimi, Hamid Reza; Sahebkar, Amirhossein

doi:10.1007/978-3-030-56153-6_3

Cited by 7 publications

(5 citation statements)

References 90 publications

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“…Among the polyphenols, curcumin, the bioactive compound derived from the rhizome of Curcuma longa , exhibits immunomodulatory, antioxidant, neuroprotective, and remyelinating properties, which make it a good candidate as an adjuvant molecule in the treatment of MS [ 54 ]. In detail, curcumin exerts inhibitory effects on the autoimmune responses through interfering with the activation of nuclear factor kappa B, a key transcription factor involved in the regulation of the immune and inflammatory genes in MS [ 54 ]. The NF-κB inhibition causes a decrease in the release of pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6 [ 55 , 56 ].…”

Section: Natural Compounds Of Interest In Msmentioning

confidence: 99%

Exploring the Therapeutic Potential: Bioactive Molecules and Dietary Interventions in Multiple Sclerosis Management

Tancreda,

Ravera,

Panfoli

2024

CIMB

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Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system, the etiology of which is still unclear. Its hallmarks are inflammation and axonal damage. As a disease primarily impacting younger individuals, the social cost of MS is high. It has been proposed that environmental factors, smoking, and dietary habits acting on a genetic susceptibility play a role in MS. Recent studies indicate that diet can significantly influence the onset and progression of MS. This review delves into the impact of natural bioactive molecules on MS development and explores the dietary interventions that hold promise in managing the disease. Dietary patterns, including ketogenic and Mediterranean diets, are discussed. Theories about the potential mechanistic associations beneath the noted effects are also proposed. Several dietary components and patterns demonstrated the potential for a significant impact on MS. However, extensive prospective clinical trials are necessary to fully understand the role of natural bioactive molecules as disease modifiers in MS.

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Section: Natural Compounds Of Interest In Msmentioning

confidence: 99%

Exploring the Therapeutic Potential: Bioactive Molecules and Dietary Interventions in Multiple Sclerosis Management

Tancreda,

Ravera,

Panfoli

2024

CIMB

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“…Kurkumin juga dapat menurunkan kadar sitokin sitokin inflamasi seperti misalnya tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β) (Singh & Vinayak, 2015). Kurkumin menghambat nuclear factor-kappa B (NF-κB), yang berperan sebagai regulator inflamasi (Gachpazan et al, 2021). Aktivasi NF-κB akan meningkatkan transkripsi gen pro-inflamasi, dan dengan menghambat jalur ini, kurkumin dapat menekan peradangan pada tingkat molekuler.…”

Section: Kurkuminunclassified

Peran Nutrasetikal dalam Mitigasi Inflamasi Kronis: Tinjauan Pustaka

Setiawan,

Ernawati

2024

Calvaria

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Pendahuluan: Inflamasi kronis adalah respon biologis kompleks terhadap stimulus berbahaya seperti patogen, sel rusak, dan iritan, yang berperan penting dalam penyakit kronis. Tujuan: Tinjauan pustaka ini bertujuan untuk menganalisis bukti ilmiah terkini mengenai mekanisme anti-inflamasi nutrasetikal dan potensi dalam mitigasi inflamasi kronis. Metode: Pencarian literatur dilakukan menggunakan PubMed, Scopus, dan Google Scholar, dengan fokus pada kata kunci seperti "nutrasetikal," "inflamasi kronis," "mekanisme anti-inflamasi," "kurkumin," "omega-3," "resveratrol," "quercetin," dan "jahe (Zingiber officinale)." Artikel yang dipilih meliputi penelitian asli, tinjauan pustaka, dan meta-analisis yang dipublikasikan dalam 10 tahun terakhir, terutama pada mekanisme kerja anti-inflamasi senyawa nutrasetikal pada. Hasil: Nutrasetikal seperti kurkumin, asam lemak omega-3, resveratrol, quercetin, dan jahe menunjukkan efek anti-inflamasi yang signifikan dengan menghambat jalur pro-inflamasi, mengurangi stres oksidatif, dan menurunkan produksi sitokin pro-inflamasi. Kurkumin menghambat enzim COX-2 dan iNOS serta menekan aktivasi NF-κB. Asam lemak omega-3 menghambat produksi eikosanoid dan memodulasi faktor transkripsi. Resveratrol menghambat aktivasi NF-κB dan mempengaruhi mikrobiota usus. Quercetin menghambat enzim COX-2 dan LOX serta memodulasi fungsi sel sel imun. Jahe mengandung senyawa bioaktif yang menghambat COX-2 dan iNOS, mengurangi stres oksidatif, dan menekan aktivasi NF-κB.. Kesimpulan: Nutrasetikal menunjukkan potensi yang menjanjikan dalam mitigasi inflamasi kronis melalui berbagai mekanisme. Penelitian lebih lanjut diperlukan untuk memperjelas mekanisme molekuler dan mengembangkan pedoman klinis untuk penggunaannya. Kata kunci: Nutrasetikal, inflamasi kronis, senyawa bioaktif, mekanisme kerja.

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“…Nuclear factor kappa beta (NF-kβ) transcription controls a large number of genes that are connected to the induction of immunological responses as well as acute and inflammatory responses. Curcumin prevents NF-kβ activation which has captivating therapeutic potential for neurological diseases and causes a down-regulation of particular inflammatory genes (Gachpazan et al, 2021).…”

Section: Curcuma Longamentioning

confidence: 99%

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

Sajid,

Abbas,

Khan

et al. 2023

Complementary and Alternative Medicine: One Health Perspective

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The phrase "neurodegenerative diseases" refers to conditions that cause a major loss of neurons, both structurally and functionally. Neurodegenerative diseases are serious life-threatening in which neural cells in the brain stop working or die. One of the most recently discovered pathogenic processes in the genesis of neurological illnesses is mitochondrial dysfunction. Mitochondria play a significant role in various cellular processes such as the production of ATP, intracellular calcium, and generation of reactive oxygen species and improper function leads to diseases. Oxidative stress and aging are two other prevalent etiologies of neurological diseases. Several side effects have emerged as a result of current treatment methods and the progressive nature of illnesses, prompting patients to switch to other medications. The helpful impact of medicinal plants in these situations has been attributed to their demonstration through several cellular and molecular processes. Traditional plants have a few neuroprotective mechanisms: they reduce inflammatory responses, regulate pro-inflammatory cytokines' functional aspects such as tumor growth, and enhance antioxidant qualities. Plant prevention strategies for these diseases heavily rely on variations in transcription and transduction pathways. Some of the therapeutic herbs for preventing neurological disorders are Panax ginseng, Curcuma longa, Zingiber officinale, Ginkgo biloba, and Utrica diocia, etc., have shown antioxidant as well as anti-inflammatory effects and also show a promising tool for treating neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, multiple sclerosis, and epilepsy. Medicinal plants contain various phytochemical constituents that improve oxidative stress, reduce mitochondrial damage, and protect against brain damage. In short, use of whole plants or parts of medicinal plants from roots to seeds extracted chemicals are used to prevent neurodegenerative illnesses.

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Targeting Nuclear Factor-Kappa B Signaling Pathway by Curcumin: Implications for the Treatment of Multiple Sclerosis

Cited by 7 publications

References 90 publications

Exploring the Therapeutic Potential: Bioactive Molecules and Dietary Interventions in Multiple Sclerosis Management

Exploring the Therapeutic Potential: Bioactive Molecules and Dietary Interventions in Multiple Sclerosis Management

Peran Nutrasetikal dalam Mitigasi Inflamasi Kronis: Tinjauan Pustaka

Prominent Medicinal Plants for the Treatment of Neurodegenerative Disorders

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