Targeting of cold-inducible RNA-binding protein alleviates sepsis via alleviating inflammation, apoptosis and oxidative stress in heart

Apelin ameliorates sepsis-induced myocardial dysfunction via inhibition of NLRP3-mediated pyroptosis of cardiomyocytes

“…Although our study has several promising findings, several limitations should be acknowledged. First, There is mounting evidence that overproduction of ROS plays a critical role in the regulation of SMD [ 48 , 49 ]. Although we showed that NLRP3 mediated pyroptosis and inflammation contribute to SMD in the current study, whether Apelin attenuates SMD via regulation of ROS production warrants investigation.…”