Targeting of oxidative stress and inflammation through ROS/NF-kappaB pathway in phosphine-induced hepatotoxicity mitigation

Haghi‐Aminjan, Hamed; Abtahi, Seyed Reza; Hazrati, Ebrahim; Chamanara, Mohsen; Jalili, Maryam; Paknejad, Babak

doi:10.1016/j.lfs.2019.116607

Cited by 77 publications

(49 citation statements)

References 71 publications

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“…The cell inflammatory response involves the secretion of various inflammatory cytokines [34,35]. Transcription factor NFκB regulates many cytokines' production, while its level is upregulated in certain chronic diseases [36,37]. In this study, GA-treated REF cells demonstrated a decreased concentration of NFκB (p < 0.001) and inflammatory cytokines, including TNFα (p < 0.001), IL-1β (p < 0.01), and IL-6 (p < 0.001), compared to the H 2 O 2 group.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Gallic Acid in Regulating Senescence and Diabetes; an In Vitro Study

et al. 2020

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Gallic acid (GA), a plant-derived ubiquitous secondary polyphenol metabolite, can be a useful dietary supplement. This in vitro study’s primary purpose was to assess the anti-aging properties of GA using rat embryonic fibroblast (REF) cells, antidiabetic effects via pancreatic islet cells, and finally, elucidating the molecular mechanisms of this natural compound. REF and islet cells were isolated from fetuses and pancreas of rats, respectively. Then, several senescence-associated molecular and biochemical parameters, along with antidiabetic markers, were investigated. GA caused a significant decrease in the β-galactosidase activity and reduced inflammatory cytokines and oxidative stress markers in REF cells. GA reduced the G0/G1 phase in senescent REF cells that led cells to G2/M. Besides, GA improved the function of the β cells. Flow cytometry and spectrophotometric analysis showed that it reduces apoptosis via inhibiting caspase-9 activity. Taken together, based on the present findings, this polyphenol metabolite at low doses regulates different pathways of senescence and diabetes through its antioxidative stress potential and modulation of mitochondrial complexes activities.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Gallic Acid in Regulating Senescence and Diabetes; an In Vitro Study

et al. 2020

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“…Oxidative stress is reported to associate with the development of several metabolic, chronic disorders or cancers (Finkel and Holbrook, 2000;Reuter et al, 2010;Aminjan et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

et al. 2020

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Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies in which oxidative stress seems to be one of the causes. In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases. Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed.

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“…Under steady-state conditions, ROS molecules are scavenged by various antioxidant defense mechanisms [5]. In this sense, the antioxidant potential of plants has attracted a great deal of attention, because increased oxidative stress has been reported as a major contributing factor to both the development and progression of aging and numerous life-threatening disorders, including neurodegenerative and cardiovascular diseases [6,7].…”

Section: Introductionmentioning

confidence: 99%

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

Azzini²,

et al. 2020

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Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hundreds of biologically active constituents are present in each whole plant matrix, providing promissory bioactive effects for human beings. Indeed, the worldwide population has devoted increased attention and preference for the use of medicinal plants for healthy aging and longevity promotion. In fact, plant-derived bioactives present a broad spectrum of biological effects, and their antioxidant, anti-inflammatory, and, more recently, anti-aging effects, are considered to be a hot topic among the medical and scientific communities. Nonetheless, despite the numerous biological effects, it should not be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview of plant-derived bioactives in age-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion. Finally, an eye-opening look into the overall evidence of plant compounds related to longevity is presented.

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Targeting of oxidative stress and inflammation through ROS/NF-kappaB pathway in phosphine-induced hepatotoxicity mitigation

Cited by 77 publications

References 71 publications

Therapeutic Effects of Gallic Acid in Regulating Senescence and Diabetes; an In Vitro Study

Therapeutic Effects of Gallic Acid in Regulating Senescence and Diabetes; an In Vitro Study

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

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