Targeting of Protein’s Messenger RNA for Viral Replication, Assembly and Release in SARS-CoV-2 Using Whole Genomic Data From South Africa: Therapeutic Potentials of Cannabis Sativa L

Erukainure, Ochuko L.; Matsabisa, Motlalepula G.; Muhammad, Aliyu; Abarshi, M.M.; Amaku, James F.; Katsayal, Sanusi B.; Nde, Adeline Lum

doi:10.3389/fphar.2021.736511

Cited by 7 publications

(5 citation statements)

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“…The summary of evidence suggesting that CBG may represent a lead antimicrobial cannabinoid is illuminating [ 12 ]. Further, there is a pressing interest in the potential of cannabinoids, such as CBD, to inhibit SARS-CoV-2 cellular entry and replication through varying mechanisms [ 48 , 49 , 101 ]. This review augments these prior articles by focusing on the most recent literature on cannabis-related antimicrobials, primarily summarized in Table 1 , Table 2 , Table 3 , Table 4 and Table 5 , and providing a synopsis of the knowledge gaps that act as a barrier to the acceptance and utility of cannabinoid-based antimicrobial therapeutics.…”

Section: Discussionmentioning

confidence: 99%

“…CB1 and CB2, at least at the mRNA level, are upregulated in circulating immune cells in individuals with moderate to severe disease [ 100 ]. One report found that several cannabinoids, including tetrahydrocannabivarin (THCV), THC, CBG, and CBN, are computationally predicted to interact with mRNAs encoding proteins assumed to be involved in SARS-CoV-2 replication, translation, assembly and release (ORF1ab, surface glycoprotein, envelope protein, nucleocapsid phosphoprotein) [ 101 ], although effective inhibition of such a broad range of translational events has yet to be confirmed in vitro or in vivo. Altyar et al screened, in silico, 45 cannabinoids for their potential to interact with key SARS-CoV-2 enzymes, noting that cannabichromanon (CBCN) was best suited as a potential inhibitor of MPro and Plpro [ 102 ].…”

Section: Translational Considerations For the Development Of Cannabis...mentioning

confidence: 99%

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The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics

et al. 2022

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Cannabinoid receptor 2 (CB2) is of interest as a much-needed target for the treatment or prevention of several neurogenerative diseases. However, CB2 agonists, particularly phytocannabinoids, have been ascribed antimicrobial properties and are associated with the induction of microbiome compositional fluxes. When developing novel CB2 therapeutics, CB2 engagement and antimicrobial functions should both be considered. This review summarizes those cannabinoids and cannabis-informed molecules and preparations (CIMPs) that show promise as microbicidal agents, with a particular focus on the most recent developments. CIMP–microbe interactions and anti-microbial mechanisms are discussed, while the major knowledge gaps and barriers to translation are presented. Further research into CIMPs may proffer novel direct or adjunctive strategies to augment the currently available antimicrobial armory. The clinical promise of CIMPs as antimicrobials, however, remains unrealized. Nevertheless, the microbicidal effects ascribed to several CB2 receptor-agonists should be considered when designing therapeutic approaches for neurocognitive and other disorders, particularly in cases where such regimens are to be long-term. To this end, the potential development of CB2 agonists lacking antimicrobial properties is also discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Translational Considerations For the Development Of Cannabis...mentioning

confidence: 99%

The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics

et al. 2022

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“…Erukainure et al. ( 2021 ) studied the phytochemical constituents of Cannabis sativa L. (Cannabaceae). Through MD, it was found that cannabinol, tetrahydrocannabivarin, tetrahydrocannabinol, cannabispiran, cannabidiol, and cannabigerol have binding affinities ranging from −40.78 to −36.21 kcal −1 for the nucleocapsid phosphoprotein translation initiation site and nucleocapsid phosphoprotein translation termination site.…”

Section: Assembly and Release Inhibitors Against Sars-cov-2mentioning

confidence: 99%

Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets

He,

Yuan,

Zhang

et al. 2023

Pharmaceutical Biology

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Context Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still ongoing and currently the most striking epidemic disease. With the rapid global spread of SARS-CoV-2 variants, new antivirals are urgently needed to avert a more serious crisis. Inhibitors from traditional medicines or natural plants have shown promising results to fight COVID-19 with different mechanisms of action. Objectives To provide comprehensive and promising approaches to the medical community in the fight against this epidemic by reviewing potential plant-derived anti-SARS-CoV-2 inhibitors. Methods Structural databases such as TCMSP ( http://lsp.nwu.edu.cn/tcmsp.php ), TCM Database @ Taiwan ( http://tcm.cmu.edu.tw/ ), BATMAN-TCM ( http://bionet.ncpsb.org/batman-tcm/ ) and TCMID ( http://www.megabionet.org/tcmid/ ), as well as PubMed, Sci Finder, Research Gate, Science Direct, CNKI, Web of Science and Google Scholar were searched for relevant articles on TCMs and natural products against SARS-CoV-2. Results Seven traditional Chinese medicines formulas have unique advantages in regulating the immune system for treating COVID-19. The plant-derived natural compounds as anti-SARS-CoV-2 inhibitors were identified based on 5 SARS-CoV-2 key proteins, namely, angiotensin-converting enzyme 2 (ACE2), 3 C-like protease (3CLpro), papain-like protease (PLpro), spike (S) protein, and nucleocapsid (N) protein. Conclusions A variety of natural products, such as flavonoids, terpenoids, phenols, and alkaloids, were identified, which could be used as potential SASR-Cov-2 inhibitors. These shed new light on the efficient discovery of SASR-Cov-2 inhibitors from natural products.

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“…Natural compounds are promising targets for drug development, and a number of therapies have been inspired and based on natural products [21]. Molecular docking analysis revealed strong binding affinities between the phytocannabinoids and codon mRNAs of proteins implicated in replication, translation and release of SARS-CoV-2, which portrays cannabinoids as potential drugs against COVID-19 [22]. Moreover, inhibition of the main protease among coronaviruses-M pro , which plays a significant role in the COVID-19 virus replication process-is also considered a potential therapeutic target [23,24].…”

Section: Antiviral Properties Of Cannabinoidsmentioning

confidence: 99%

Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 Infection

Janecki

Graczyk

Lewandowska

et al. 2022

IJMS

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The COVID-19 pandemic caused by the SARS-CoV-2 virus made it necessary to search for new options for both causal treatment and mitigation of its symptoms. Scientists and researchers around the world are constantly looking for the best therapeutic options. These difficult circumstances have also spurred the re-examination of the potential of natural substances contained in Cannabis sativa L. Cannabinoids, apart from CB1 and CB2 receptors, may act multifacetedly through a number of other receptors, such as the GPR55, TRPV1, PPARs, 5-HT1A, adenosine and glycine receptors. The complex anti-inflammatory and antiviral effects of cannabinoids have been confirmed by interactions with various signaling pathways. Considering the fact that the SARS-CoV-2 virus causes excessive immune response and triggers an inflammatory cascade, and that cannabinoids have the ability to regulate these processes, it can be assumed that they have potential to be used in the treatment of COVID-19. During the pandemic, there were many publications on the subject of COVID-19, which indicate the potential impact of cannabinoids not only on the course of the disease, but also their role in prevention. It is worth noting that the anti-inflammatory and antiviral potential are shown not only by well-known cannabinoids, such as cannabidiol (CBD), but also secondary cannabinoids, such as cannabigerolic acid (CBGA) and terpenes, emphasizing the role of all of the plant’s compounds and the entourage effect. This article presents a narrative review of the current knowledge in this area available in the PubMed, Scopus and Web of Science medical databases.

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Targeting of Protein’s Messenger RNA for Viral Replication, Assembly and Release in SARS-CoV-2 Using Whole Genomic Data From South Africa: Therapeutic Potentials of Cannabis Sativa L

Cited by 7 publications

References 57 publications

The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics

The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics

Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets

Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 Infection

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