Targeting peptide‐based quorum sensing systems for the treatment of gram‐positive bacterial infections

Milly, Tahmina Ahmed; Tal‐Gan, Yftah

doi:10.1002/pep2.24298

Cited by 9 publications

(5 citation statements)

References 105 publications

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“…Targeting AIPs is a good way of treating QS and considerable effort has been made to date to find inhibitors [100]. A known approach suggested in this context is to cope with RNAIII, due to its key role in QS.…”

Section: Anti-qs Approachesmentioning

confidence: 99%

Quorum Sensing in Biofilm

Sedarat,

W. Taylor-Robinson

2024

Recent Advances in Bacterial Biofilm Studies - Formation, Regulation, and Eradication in Human Infections

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Quorum sensing (QS) is a complex system of communication used by bacteria, including several notable pathogens that pose a significant threat to public health. The central role of QS in biofilm activity has been demonstrated extensively. The small extracellular signaling molecules, known as autoinducers, that are released during this process of cell-to-cell communication play a key part in gene regulation. QS is involved in such diverse intracellular operations as modulation of cellular function, genetic material transfer, and metabolite synthesis. There are three main types of QS in bacteria, metabolites of which may form the target for novel treatment approaches. The autoinducing peptide system exists only in Gram-positive bacteria, being replaced in Gram-negative species by the acyl-homoserine lactone system, whereas the autoinducer-2 system occurs in both.

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Section: Anti-qs Approachesmentioning

confidence: 99%

Quorum Sensing in Biofilm

Sedarat,

W. Taylor-Robinson

2024

Recent Advances in Bacterial Biofilm Studies - Formation, Regulation, and Eradication in Human Infections

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“…This processing is significant for the regulation of plasmid transfer and other cell-signaling processes in E. faecalis. The Eep gene is not directly involved in quorum sensing but plays a crucial role in the production and maturation of specific peptide pheromones in E. faecalis [180,181]. Additionally, the extracytoplasmic function (ECF) sigma factor RsiV, the anti-sigma factor for sigV, is processed more easily by the protease encoded by Eep [182], which contributes to stress resistance.…”

Section: Eepmentioning

confidence: 99%

“…The Fsr locus regulates the transcription of the gelatinase gene (gelE) and the serine protease gene (sprE), and it is an integral component in the expression of virulenceenhancing factors, including biofilm formation. These and 75 other genes, including bopD, a crucial gene for biofilm formation, are inhibited if the Fsr quorum-sensing system is compromised [180,189].…”

Section: The Fsr Operon and Ef1097 Locusmentioning

confidence: 99%

The Science behind Biofilm: Unraveling Enterococcus Genus’ Remarkable Ability to Produce Microbial Communities

Pirbonyeh,

Emami,

Javanmardi

2024

Infectious Diseases

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The remarkable ability of Enterococcus to produce microbial communities, specifically biofilms, is a topic of interest in scientific research. Biofilms formed by Enterococcus species, are known to contribute to their survival in extreme environments and their involvement in persistent bacterial infections. The aim of this chapter is to provide a comprehensive understanding of the mechanisms underlying biofilm formation in clinically important species such as E. faecalis and the increasingly drug-resistant but less well-studied E. faecium. Enterococcus forms biofilms through a complex interaction between genes and virulence factors such as DNA release, cytolysin, pili, secreted antigen A, and microbial surface components that recognize adhesive matrix molecules (MSCRAMMs). Quorum sensing mediated by peptide pheromones targets gene expression and regulation and is essential for the coordination of biofilm formation. Furthermore, control over extracellular DNA (eDNA) release has been shown to be crucial for biofilm formation. In E. faecalis, autolysin N-acetylglucosaminidase and proteases such as serine protease and gelatinase are important players in this process, influencing biofilm development and virulence. The study of biofilm formation in Enterococcus can provide insights into the pathogenesis of opportunistic infections and their prevention and provide directions for future anti-biofilm therapeutic research.

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“…In addition, several naturally occurring brominated furanones have the ability to inhibit the LuxS enzyme in a concentration-dependent manner [ 161 ]. There are many reviews on QS molecules as targets for biofilm disruption [ 162 , 163 ].…”

Section: Biofilm Disruption Strategiesmentioning

confidence: 99%

Light-Based Anti-Biofilm and Antibacterial Strategies

et al. 2023

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Biofilm formation and antimicrobial resistance pose significant challenges not only in clinical settings (i.e., implant-associated infections, endocarditis, and urinary tract infections) but also in industrial settings and in the environment, where the spreading of antibiotic-resistant bacteria is on the rise. Indeed, developing effective strategies to prevent biofilm formation and treat infections will be one of the major global challenges in the next few years. As traditional pharmacological treatments are becoming inadequate to curb this problem, a constant commitment to the exploration of novel therapeutic strategies is necessary. Light-triggered therapies have emerged as promising alternatives to traditional approaches due to their non-invasive nature, precise spatial and temporal control, and potential multifunctional properties. Here, we provide a comprehensive overview of the different biofilm formation stages and the molecular mechanism of biofilm disruption, with a major focus on the quorum sensing machinery. Moreover, we highlight the principal guidelines for the development of light-responsive materials and photosensitive compounds. The synergistic effects of combining light-triggered therapies with conventional treatments are also discussed. Through elegant molecular and material design solutions, remarkable results have been achieved in the fight against biofilm formation and antibacterial resistance. However, further research and development in this field are essential to optimize therapeutic strategies and translate them into clinical and industrial applications, ultimately addressing the global challenges posed by biofilm and antimicrobial resistance.

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Targeting peptide‐based quorum sensing systems for the treatment of gram‐positive bacterial infections

Cited by 9 publications

References 105 publications

Quorum Sensing in Biofilm

Quorum Sensing in Biofilm

The Science behind Biofilm: Unraveling Enterococcus Genus’ Remarkable Ability to Produce Microbial Communities

Light-Based Anti-Biofilm and Antibacterial Strategies

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