Targeting PPARs for therapy of atherosclerosis: A review

Miao, Miao; Wang, X.M.; Tian, Li; Li, Yanjie; Yu, Wenqian; Yang, Tong-Mei; Guo, Shoudong

doi:10.1016/j.ijbiomac.2023.125008

Cited by 15 publications

(31 citation statements)

References 345 publications

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“…The PPARs were first discovered in 1990, since then their different isoforms have been reported. Currently, three different isoforms including PPAR-α, PPAR-β/δ, and PPAR-γ were found in different tissues in the human body (Miao et al, 2023;Takada & Makishima, 2020). They play pivotal roles in energy metabolism, especially fatty acid metabolism.…”

Section: Peroxisome Proliferator-activated Receptorsmentioning

confidence: 99%

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

Liu

Zhang

et al. 2023

Phytotherapy Research

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Cardiovascular diseases are currently the primary cause of mortality in the whole world. Growing evidence indicated that the disturbances in cardiac fatty acid metabolism are crucial contributors in the development of cardiovascular diseases. The abnormal cardiac fatty acid metabolism usually leads to energy deficit, oxidative stress, excessive apoptosis, and inflammation. Targeting fatty acid metabolism has been regarded as a novel approach to the treatment of cardiovascular diseases. However, there are currently no specific drugs that regulate fatty acid metabolism to treat cardiovascular diseases. Many traditional Chinese medicines have been widely used to treat cardiovascular diseases in clinics. And modern studies have shown that they exert a cardioprotective effect by regulating the expression of key proteins involved in fatty acid metabolism, such as peroxisome proliferator‐activated receptor α and carnitine palmitoyl transferase 1. Hence, we systematically reviewed the relationship between fatty acid metabolism disorders and four types of cardiovascular diseases including heart failure, coronary artery disease, cardiac hypertrophy, and diabetic cardiomyopathy. In addition, 18 extracts and eight monomer components from traditional Chinese medicines showed cardioprotective effects by restoring cardiac fatty acid metabolism. This work aims to provide a reference for the finding of novel cardioprotective agents targeting fatty acid metabolism.

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Section: Peroxisome Proliferator-activated Receptorsmentioning

confidence: 99%

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

Liu

Zhang

et al. 2023

Phytotherapy Research

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“…Ligand activation triggers conformational changes of PPAR-RXR and finally activate the transcription of target genes. Notably, PPARs regulate multiple genes associated with cellular lipid metabolism and inflammation in cardiovascular system ( 14 ). Downregulation of PPARα is found to decrease hepatic de novo lipogenesis, while PPARα agonists restore lipid homeostasis in the liver ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, activated PPARs can interact with other transcription factors that are involved in inflammation, such as activator protein 1 (AP-1) and nuclear factor kappa B (NF-κB), resulting in transcriptional repression ( 14 , 20 ). For instance, PPARα activation suppresses inflammatory responses in different cells by inhibiting TLR4/NF-κB and AP-1 signaling pathways ( 14 , 17 – 22 ). PPARβ is demonstrated to decrease inflammation via activation of AMP-activated protein kinase (AMPK) and inactivation of mitogen-activated protein kinase (MAPK) signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

“…PPARβ is demonstrated to decrease inflammation via activation of AMP-activated protein kinase (AMPK) and inactivation of mitogen-activated protein kinase (MAPK) signaling pathways. However, deletion or repression of PPARβ expression in myeloid cells also decreases atherosclerosis and inflammatory molecules by modulating the PPARβ/B cell lymphoma 6 axis ( 14 , 23 ). Moreover, PPARγ activation has been demonstrated to inhibit release of inflammatory factors via activating AMPK and suppressing multiple signaling pathways including TLR4, MAPK, and WNT/β-catenin ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, deletion or repression of PPARβ expression in myeloid cells also decreases atherosclerosis and inflammatory molecules by modulating the PPARβ/B cell lymphoma 6 axis ( 14 , 23 ). Moreover, PPARγ activation has been demonstrated to inhibit release of inflammatory factors via activating AMPK and suppressing multiple signaling pathways including TLR4, MAPK, and WNT/β-catenin ( 14 ). Therefore, PPARs are considered as important targets for CVD therapy and other diseases.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Zhang,

Shi

et al. 2024

Front. Cardiovasc. Med.

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Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and control the expression of multiple genes that are involved in lipid metabolism and inflammatory responses. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy. Natural products are structural diversity and have a good safety. Recent studies find that natural herbs and compounds exhibit attractive therapeutic effects on atherosclerosis by alleviating hyperlipidemia and inflammation through modulation of PPARs. Importantly, the preparation of natural products generally causes significantly lower environmental pollution compared to that of synthesized chemical compounds. Therefore, it is interesting to discover novel PPAR modulator and develop alternative strategies for atherosclerosis therapy based on natural herbs and compounds. This article reviews recent findings, mainly from the year of 2020 to present, about the roles of natural herbs and compounds in regulation of PPARs and their therapeutic effects on atherosclerosis. This article provides alternative strategies and theoretical basis for atherosclerosis therapy using natural herbs and compounds by targeting PPARs, and offers valuable information for researchers that are interested in developing novel PPAR modulators.

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Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: focus on PPARs, LXRs, and PCSK9

Palumbo,

Ugolotti,

Zimetti

et al. 2024

Atherosclerosis Plus

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Targeting PPARs for therapy of atherosclerosis: A review

Cited by 15 publications

References 345 publications

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: focus on PPARs, LXRs, and PCSK9

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