2022
DOI: 10.7150/thno.78851
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Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy

Abstract: Background:The therapeutic efficacy of allergen specific immunotherapy (SIT) is recognized, but needs improved. Psychological stress influences the immune system's function. The objective of this study is to elucidate the effects of psychological stress on compromising the effectiveness of SIT. Methods: A murine model with the airway allergic disorder (AAD) was established. Mice were treated with SIT with or without restraint stress (Rs). Results: Rs was found to significantly hamper the efficacy of SIT in mic… Show more

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Cited by 2 publications
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“…Given the patterns of sensitization and exposure to major indoor allergens in the study population, it is not possible to examine mediation effects by specific allergens. It is also possible that reductions in stress may have attenuated the effects of allergen exposure, given literature that shows that psychological stress can enhance the influence of allergens on allergy and asthma correlates …”
Section: Discussionmentioning
confidence: 99%
“…Given the patterns of sensitization and exposure to major indoor allergens in the study population, it is not possible to examine mediation effects by specific allergens. It is also possible that reductions in stress may have attenuated the effects of allergen exposure, given literature that shows that psychological stress can enhance the influence of allergens on allergy and asthma correlates …”
Section: Discussionmentioning
confidence: 99%