2013
DOI: 10.1016/j.addr.2012.09.041
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Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances

Abstract: Targeting of drugs and their carrier systems by using receptor-mediated endocytotic pathways was in its nascent stages 25 years ago. In the intervening years, an explosion of knowledge focused on design and synthesis of nanoparticulate delivery systems as well as elucidation of the cellular complexity of what was previously-termed receptor-mediated endocytosis has now created a situation when it has become possible to design and test the feasibility of delivery of highly specific nanoparticle drug carriers to … Show more

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Cited by 389 publications
(280 citation statements)
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References 237 publications
(253 reference statements)
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“…[21,44,45] Active targeting is dependent on the specific ligand-receptor recognition, where nanoparticles attached with targeting moieties can bind to specific targeting cancer cells, and as a result, anchored nanoparticles enter the cells through an endocytosis pathway and release the drug within the intracellular compartments of the cells. [46] For example, compared to non-targeted magnetic nanoparticles, targeted ones with anti-HER2 monoclonal antibody specific for breast cancer cells have demonstrated 10-30-fold increased concentrations in tumor tissues. [47] Similarly, nanoparticles have also been conjugated with RGD (Arg-Gly-Asp) peptides due to their high affinity to αvβ3 integrin receptors that are highly expressed in tumor cells, thus enhancing the intratumoral drug delivery.…”
Section: Second Generation Nanomedicinesmentioning
confidence: 99%
“…[21,44,45] Active targeting is dependent on the specific ligand-receptor recognition, where nanoparticles attached with targeting moieties can bind to specific targeting cancer cells, and as a result, anchored nanoparticles enter the cells through an endocytosis pathway and release the drug within the intracellular compartments of the cells. [46] For example, compared to non-targeted magnetic nanoparticles, targeted ones with anti-HER2 monoclonal antibody specific for breast cancer cells have demonstrated 10-30-fold increased concentrations in tumor tissues. [47] Similarly, nanoparticles have also been conjugated with RGD (Arg-Gly-Asp) peptides due to their high affinity to αvβ3 integrin receptors that are highly expressed in tumor cells, thus enhancing the intratumoral drug delivery.…”
Section: Second Generation Nanomedicinesmentioning
confidence: 99%
“…The main characteristic of these receptors is that they must to be uniformly over-expressed in the target cells. The most studied target receptors for carcinogenic cells are transferrin, folate, surface glycoprotein receptors, and the epidermal growth factor receptor (Xu et al, 2013). When a tumor endothelium ligand is used, it is expected that the antineoplastic agent avoid the growth of new blood vessels and promote the death of the existing vessels.…”
Section: Active Specificitymentioning
confidence: 99%
“…UV-VIS spectra can be evaluated to measure reaction rates during the synthesis of dendrimers. The UV-VIS spectrum is easily recorded, however solvent selection plays an important role in correct measurement [147,148].…”
Section: Ultraviolet-visible Spectroscopy (Uv-vis)mentioning
confidence: 99%