Targeting self-assembled F127-peptide polymer with pH sensitivity for release of anticancer drugs

Abstract

The treatment of breast cancer mainly relies on chemotherapy drugs, which present significant side effects.

Biocompatible Polycationic Silver Nanocluster‐Impregnated PLGA Nanocomposites with Potent Antimicrobial Activity

“…The 10 mL sample was further centrifuged at 3760 g for 15 min and the supernatant analyzed using Agilent Technologies 8800 ICP‐MS Triple Quad (Agilent Technologies, Stockport, UK). The cumulative percentage amount of silver ion release was obtained by dividing the cumulative amount of silver release at each sampling interval by the initial amount of sample and multiplied by 100 (Equation 3) [55] . The experiment was performed in triplicate. $$$\vcenter{\openup.5em\halign{$\displaystyle{#}$\cr {\rm { Drug\ loading}}{\rm \ }{\rm { =}}{{{\rm { Amount\ of\ Ag}}{\rm { \ }}{\rm { in\ }}{\rm { pAgNCs@PLGA}}}\over{{\rm { Amount\ of}}{\rm { \ }}{\rm { pAgNCs@PLGA}}}}\times {\rm { \ }}{\rm { 100}}{\rm \char37 }\hfill\cr}}$$$ $$$\vcenter{\openup.5em\halign{$\displaystyle{#}$\cr {\rm { Encapsulation\ Efficiency\ }}{\rm { =}}\hfill\cr {{{\rm { Amount\ of\ Ag}}{\rm { \ }}{\rm { in\ }}{\rm { pAgNCs@PLGA}}}\over{{\rm { Amount\ of\ Feeding\ Ag}}}}\times {\rm { 100}}{\rm \char37 }\hfill\cr}}$$$ $$$\vcenter{\openup.5em\halign{$\displaystyle{#}$\cr {\rm { Cumulative\ release\ of\ silver}}{\rm { =}}\hfill\cr {{{\rm { 50\times{}}}{\rm \ }{{\rm { C}}}_{{\rm { n}}}{\rm { \ +}}{\rm { \ }}{\rm { 1\times{}}}\ \sum {{\rm { C}}}_{{\rm { n-1}}}}\over{{{\rm { Ag}}}_{{\rm { PLGA}}}}}{\rm { \ \times 100}}{\rm \char37 }\hfill\cr}}$$$ …”

“…The cumulative percentage amount of silver ion release was obtained by dividing the cumulative amount of silver release at each sampling interval by the initial amount of sample and multiplied by 100 (Equation 3). [55] The experiment was performed in triplicate.…”

The therapeutic effect of traditional Chinese medicine on breast cancer through modulation of the Wnt/β-catenin signaling pathway

“…In contrast, triple-negative breast cancer is frequently treated with chemotherapeutic agents like Doxorubicin, Cyclophosphamide, and Vinorelbine Tartrate. However, these widely used chemotherapy drugs in clinical settings are often associated with a range of side effects, including gastrointestinal disturbances ( Zhou et al, 2013 ; Sartaj et al, 2021a ; Farghadani and Naidu, 2022 ), osteoporosis ( Essex et al, 2019 ; Shapiro, 2021 ; Meyer et al, 2024 ), bone marrow suppression ( Zhou et al, 2013 ; Koliou et al, 2018 ; Han et al, 2021 ), dyslipidemia ( Duman et al, 2012 ), and drug resistance ( Sartaj et al, 2021b ; Yu S. W. et al, 2023 ). On the other hand, TCM has demonstrated broad applicability in various types and clinical stages of breast cancer.…”

Physical–Chemical Approach to Designing Drugs with Multiple Targets

“…Concurrently, the hydrophobic regions of the AMPs enable them to break into the cellular membranes or to enter the pathogenic cell and disrupt their functions with a limited likelihood of inducing resistance, ultimately inhibiting pathogenic cell replication and leading to cell death . Cancer cell membranes contain anionic lipids that can be targeted by AMPs. , Certain AMPs can also target the distinct cell surface receptors and acidic microenvironment of cancer cells. − These observations suggest that AMPs might be effectively utilized in fighting both cancer and viral infections.…”