2022
DOI: 10.1007/s10456-022-09839-4
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Targeting SMYD2 inhibits angiogenesis and increases the efficiency of apatinib by suppressing EGFL7 in colorectal cancer

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Cited by 13 publications
(8 citation statements)
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“…Angiogenesis, the process by which new capillaries grow from preexisting blood vessels, is essential for the growth and metastasis of many solid tumors, including pancreatic, colorectal, and cervical cancer ( Li et al, 2019 ; Wu et al, 2019 ; Zhang et al, 2023c ). Hypoxia is an important microenvironmental factor that determines the rate of tumor angiogenesis, and the focus of the cell’s adaptation to hypoxia is the transcription factor hypoxia-inducible factor 1 α (HIF1α) ( Paredes et al, 2021 ).…”
Section: Mechanism Of Copper In Carcinogenesismentioning
confidence: 99%
See 1 more Smart Citation
“…Angiogenesis, the process by which new capillaries grow from preexisting blood vessels, is essential for the growth and metastasis of many solid tumors, including pancreatic, colorectal, and cervical cancer ( Li et al, 2019 ; Wu et al, 2019 ; Zhang et al, 2023c ). Hypoxia is an important microenvironmental factor that determines the rate of tumor angiogenesis, and the focus of the cell’s adaptation to hypoxia is the transcription factor hypoxia-inducible factor 1 α (HIF1α) ( Paredes et al, 2021 ).…”
Section: Mechanism Of Copper In Carcinogenesismentioning
confidence: 99%
“…Interestingly, the results of a recent study also showed that copper bridges the connection between chronic inflammation and tumor development; the authors showed that, in a murine model, the inflammatory response induces copper uptake through the IL-17-STEAP4-XIAP-NFκB axis to promote colon tumorigenesis (Liao et al, 2020). Angiogenesis, the process by which new capillaries grow from preexisting blood vessels, is essential for the growth and metastasis of many solid tumors, including pancreatic, colorectal, and cervical cancer (Li et al, 2019;Wu et al, 2019;Zhang et al, 2023c). Hypoxia is an important microenvironmental factor that determines the rate of tumor angiogenesis, and the focus of the cell's adaptation to hypoxia is the transcription factor hypoxia-inducible factor 1 α (HIF1α) (Paredes et al, 2021).…”
Section: Figurementioning
confidence: 99%
“…Angiogenesis, formation of new blood vessels from pre-existing vessels, is an important event in cancer growth and hematogenous metastasis (Zhang et al, 2022;Xiong et al, 2023). Inhibition of angiogenesis with several FDA-approved inhibitors has been an established therapeutic strategy for many solid tumors (Chen et al, 2018;Liu et al, 2019;Zhang et al, 2022). Antiangiogenic effect of statins has attracted growing attention (Weis et al, 2002;Dulak and Jozkowicz, 2005;Zahedipour et al, 2022).…”
Section: Inhibiting Angiogenesismentioning
confidence: 99%
“…Several investigative studies have substantiated the capacity of BAY-598 to impede the proliferative potential of diverse solid tumor malignancies, including hepatocellular carcinoma, pancreatic adenocarcinoma, and glioblastoma multiforme. Specifically, BAY-598 can competitively bind to the SET domain of SMYD2, inhibit SMYD2's methylation modification of chromatin histones, reduce the generation of H3K9me2 and H3K36me2, cause changes in gene expression profiles, and ultimately culminating in the suppression of neoplastic cellular proliferation and metastatic dissemination [ 11 ]. This may be an important mechanism for BAY-598 to exert anti-tumor activity.…”
Section: Introductionmentioning
confidence: 99%