Targeting sub-cellular organelles for boosting precision photodynamic therapy

Attar, Gopal Singh; Kumar, Manoj; Bhalla, Vandana

doi:10.1039/d4cc02702g

Chem. Commun.

2024

DOI: 10.1039/d4cc02702g

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Targeting sub-cellular organelles for boosting precision photodynamic therapy

Gopal Singh Attar,

Manoj Kumar,

Vandana Bhalla

Abstract: Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have received increasing...

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Phage‐Templated Synthesis of Targeted Photoactive 1D‐Thiophene Nanoparticles

Costantini,

Saporetti,

Iencharelli

et al. 2024

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Thiophene‐based nanoparticles (TNPs) are promising therapeutic and imaging agents. Here, using an innovative phage‐templated synthesis, a strategy able to bypass the current limitations of TNPs in nanomedicine applications is proposed. The phage capsid is decorated with oligothiophene derivatives, transforming the virus in a 1D‐thiophene nanoparticle (1D‐TNP). A precise control of the shape/size of the nanoparticles is obtained exploiting the well‐defined morphology of a refactored filamentous M13 phage, engineered by phage display to selectively recognize the Epidermal Growth Factor Receptor (EGFR). The tropism of the phage is maintained also after the bioconjugation of the thiophene molecules on its capsid. Moreover, the 1D‐TNP proved highly fluorescent and photoactive, generating reactive oxygen species through both type I and type II mechanisms. The phototheranostic properties of this platform are investigated on biosystems presenting increasing complexity levels, from in vitro cancer cells in 2D and 3D architectures, to the in vivo tissue‐like model organism Hydra vulgaris. The phage‐templated 1D‐TNP showed photocytotoxicity at picomolar concentrations, and the ability to deeply penetrate 3D spheroids and Hydra tissues. Collectively the results indicate that phage‐templated synthesis of organic nanoparticles represents a general strategy, exploitable in many diagnostic and therapeutic fields based on targeted imaging and light mediated cell ablation.

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Phage‐Templated Synthesis of Targeted Photoactive 1D‐Thiophene Nanoparticles

Costantini,

Saporetti,

Iencharelli

et al. 2024

Small

View full text Add to dashboard Cite

show abstract

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Targeting sub-cellular organelles for boosting precision photodynamic therapy

Abstract: Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have received increasing...

Cited by 1 publication

References 225 publications

Phage‐Templated Synthesis of Targeted Photoactive 1D‐Thiophene Nanoparticles

Phage‐Templated Synthesis of Targeted Photoactive 1D‐Thiophene Nanoparticles

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