Targeting Th17 and Treg Signaling Pathways in Autoimmunity

Ghosh, Saikat; Lobera, Mercedes; Sundrud, Mark S.

doi:10.1016/b978-0-12-386009-5.00017-5

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2013

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“…TCDD is a widespread environmental pollutant with toxic effects such as endocrine disruption, immunotoxicity and liver damage. 82,83 a member of the chemokine receptor family, an important target for AIDS. Compounds 85 84 and 86 have been claimed in patents as inhibitors of HCV replication.…”

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confidence: 99%

A review of recent progress (2002-2012) on the biological activities of pyrazoles

Pérez-Fernández¹,

Goya²,

Elguero³

2013

Arkivoc

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Dedicated to Professor Rosa M. Claramunt on the occasion of her 65 th anniversary AbstractIn this review, we report the structures of 243 pyrazoles with their corresponding biological activities. All of them are represented around the common structure of the pyrazole ring even in those cases where the heterocycle is only a minor part of the molecule. The classification we have used is based on chemical structure considerations and not in terms of the therapeutic area which is the more common approach. Some general conclusions have been drawn linking structures with activities.

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confidence: 99%