Targeting the Brain

Joshi, Shailendra; Ornstein, Eugene; Bruce, Jeffrey N.

doi:10.1007/s12028-007-0034-8

Cited by 10 publications

(2 citation statements)

References 85 publications

(81 reference statements)

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“…IA drug delivery is optimal when there is low cerebral blood flow (CBF), high regional uptake, and high systemic clearance [5-7]. In previous studies, we have shown the effectiveness of TCH in improving the IA delivery or pharmacological effects of unencapsulated drugs [8-10].…”

Section: Introductionmentioning

confidence: 99%

Cationic surface charge enhances early regional deposition of liposomes after intracarotid injection

et al. 2014

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Rapid first pass uptake of drugs is necessary to increase tissue deposition after intraarterial (IA) injection. Here we tested whether brain tissue deposition of a nanoparticulate liposomal carrier could be enhanced by coordinated manipulation of liposome surface charge and physiological parameters, such as IA injection during transient cerebral hypoperfusion (TCH). Different degrees of blood-brain barrier (BBB) disruption were induced by focused ultrasound in three sets of Sprague Dawley rats. Brain tissue retention was then compared for anionic, cationic, and charge-neutral liposomes after IA injection combined with TCH. The liposomes contained a non-exchangeable carbocyanine membrane optical label that could be quantified using diffuse reflectance spectroscopy (DRS) or visualized by multispectral imaging. Real-time concentration-time curves in brain were obtained after each liposomal injection. Having observed greater tissue retention of cationic liposomes compared to other liposomes in all three groups, we tested uptake of cationic liposomes in C6 tumor bearing rats. DRS and multispectral imaging of postmortem sections revealed increased liposomal uptake by the C6 brain tumor as compared to non-tumor contralateral hemisphere. We conclude that regional deposition of liposomes can be enhanced without BBB disruption using IA injection of cationic liposomal formulations in healthy and C6 tumor bearing rats.

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Section: Introductionmentioning

confidence: 99%

Cationic surface charge enhances early regional deposition of liposomes after intracarotid injection

et al. 2014

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“…2,10 Consequently, intracarotid delivery can serve as the primary method of drug delivery or the technique could be used to increase the effectiveness of other methods of brain-selective drug delivery that target specific characteristics of the blood brain barrier (BBB). 11 Currently, intracarotid drugs are used for localizing neurological functions in the brain, and for the treatment of intractable cerebral vasospasm, ischemic strokes, and intracranial malignancies. 12 …”

Section: Introductionmentioning

confidence: 99%

Intracarotid Delivery of Drugs

Joshi¹,

Meyers

Ornstein³

2008

Anesthesiology

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The major efforts to selectively deliver drugs to the brain in the last decade have relied on smart molecular techniques to penetrate the blood brain barrier while intraarterial drug delivery has drawn relatively little attention. In the last decade there have been rapid advances in endovascular techniques. Modern endovascular procedures can permit highly targeted drug delivery by intracarotid route. Intracarotid drug delivery can be the primary route of drug delivery or it could be used to facilitate the delivery of smart-neuropharmaceuticals. There have been few attempts to systematically understand the kinetics of intracarotid drugs. Anecdotal data suggests that intracarotid drug delivery is effective in the treatment of cerebral vasospasm, thromboembolic strokes, and neoplasms. Neuroanesthesiologists are frequently involved in the care of such high-risk patients. Therefore, it is necessary to understand the applications of intracarotid drug delivery and the unusual kinetics of intracarotid drugs.

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The History, Current Status, and Future of the StealthStation Treatment Guidance System

Bucholz¹,

McDurmont²

2009

Textbook of Stereotactic and Functional Neurosurgery

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Targeting the Brain

Cited by 10 publications

References 85 publications

Cationic surface charge enhances early regional deposition of liposomes after intracarotid injection

Cationic surface charge enhances early regional deposition of liposomes after intracarotid injection

Intracarotid Delivery of Drugs

The History, Current Status, and Future of the StealthStation Treatment Guidance System

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