Targeting the exposome: does correcting vitamin D deficiency have potential to treat and prevent asthma?

Pfeffer, Paul

doi:10.1080/1744666x.2018.1440207

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…There is plenty of evidence to support our results that vitamin D acts on the cells of the innate and adaptive immune systems as well as on structural cells in the airways, with its deficiency promoting inflammation and its supplementation alleviating these effects [3.4.6]. Our results are consistent with what many [36][37][38][39] have suggested that vitamin D supplementation had the capacity to reduce asthma exacerbations and improve asthma control, especially in patients with severe asthma and low vitamin D status. It is more readily explicable, based on the principle that people who are the most deficient in a micronutrient will be the most likely to respond to its replacement.…”

Section: Discussionsupporting

confidence: 89%

Association between vitamin D status and asthma control: A meta-analysis of randomized trials

Wang

Liu

Wang

et al. 2019

Respiratory Medicine

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Background: There is a controversy in terms of the efficacy of vitamin D supplementation in improving asthma symptom control. Moreover, whether there is a difference in the treatment effect with respect to baseline vitamin D status remains unknown. This meta-analysis was to assess the correlations of vitamin D status with asthmarelated respiratory outcomes. Methods: PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials of vitamin D supplementation in patients with asthma. Primary outcomes were the rate of asthma exacerbation and predicted percentage of forced expiratory volume in first second (FEV 1 %). Secondary outcomes were asthma control test (ACT) scores, fractional exhaled nitric oxide (FeNO), interleukin-10 (IL-10) and adverse events. Results: A total of 14 randomized controlled trials (1421 participants) fulfilled the inclusion. Vitamin D supplementation was associated with a significant reduction in the rate of asthma exacerbation by 27% (RR: 0.73 95%Cl (0.58-0.92)). In subgroup analysis, the protective effect of exacerbation was restricted in patients with vitamin D insufficiency (vitamin D < 30 ng/ml) (RR: 0.76 95%Cl (0.61-0.95)). An improvement of FEV 1 % was demonstrated in patients with vitamin D insufficiency and air limitation (FEV 1 % < 80%) (MD: 8.3 95%Cl (5.95-10.64). No significant difference was observed in ACT scores, FeNO, IL-10 and adverse events. Conclusions: Vitamin D supplementation reduced the rate of asthma exacerbation, especially in patients with vitamin D insufficiency. Additionally, the benefit of vitamin D had a positive effect on pulmonary function in patients with air limitation and vitamin D insufficiency.

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Section: Discussionsupporting

confidence: 89%

Association between vitamin D status and asthma control: A meta-analysis of randomized trials

Wang

Liu

Wang

et al. 2019

Respiratory Medicine

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“…Conducting a real-world trial of vitamin D supplementation to specifically protect against pollution-induced asthma exacerbations will be challenging given the difficulties with clinical trials of vitamin supplementation. 47,82 However, clinical trials of this type may be necessary to build the evidence base of how we can protect ourselves from air pollution.…”

Section: Potential Pharmacotherapies To Protect Patients With Asthma Against Air Pollutionmentioning

confidence: 99%

Air Pollution and Asthma

Pfeffer

Mudway

Grigg

2021

Chest

Self Cite

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“…In another meta-analysis, it was also shown that vitamin D reduces the rate of asthma exacerbations requiring treatment with systemic corticosteroids. Interestingly, this study [13] and other studies have highlighted the benefit of vitamin D in individuals with low baseline levels of 25(OH)D [14,15]. Wang et al, for example, have shown that asthmatic patients with vitamin D insufficiency (vitamin D < 30 ng/ml) displayed reduced rate of asthma exacerbation by 27% upon vitamin D supplementation.…”

Section: Open Accessmentioning

confidence: 60%

Section: Vitamin D and Asthmamentioning

confidence: 87%

Recent advances in vitamin D implications in chronic respiratory diseases

et al. 2022

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Chronic airway inflammatory and infectious respiratory diseases are the most common medical respiratory conditions, associated with significant morbidity and mortality. Vitamin D (1,25(OH)2D3) deficiency has been shown to be highly prevalent in patients with chronic airway inflammatory and infectious diseases, correlated with increased disease severity. It has been established that vitamin D modulates ongoing abnormal immune responses in chronic respiratory diseases and is shown to restrict bacterial and viral colonization into the lungs. On the contrary, other studies revealed controversy findings regarding vitamin D efficacy in respiratory diseases. This review aims to update the current evidence regarding the role of vitamin D in airway inflammation and in various respiratory diseases. A comprehensive search of the last five years of literature was conducted using MEDLINE and non-MEDLINE PubMed databases, Ovid MEDLINE, SCOPUS-Elsevier, and data from in vitro and in vivo experiments, including clinical studies. This review highlights the importance of understanding the full range of implications that vitamin D may have on lung inflammation, infection, and disease severity in the context of chronic respiratory diseases.

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Targeting the exposome: does correcting vitamin D deficiency have potential to treat and prevent asthma?

Cited by 7 publications

References 25 publications

Association between vitamin D status and asthma control: A meta-analysis of randomized trials

Association between vitamin D status and asthma control: A meta-analysis of randomized trials

Air Pollution and Asthma

Recent advances in vitamin D implications in chronic respiratory diseases

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