Targeting the GABAB Receptor for the Treatment of Epilepsy

Joshi, Krutika; Cortez, Miguel A.; Snead, O. Carter

doi:10.1007/978-3-319-46044-4_10

Cited by 6 publications

(2 citation statements)

References 71 publications

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“…However, some studies demonstrated normal or increased LICI in patients with epilepsy. It would be anticipated that patients with seizure disorders have GABAergic inhibitory deficits, as this is supported by previous studies that have consistently shown the alterations in GABAergic transmission, especially in patients with absence seizures as well as in mouse models of generalized and focal seizures (108). The non-significant findings in studies of LICI with epilepsy patients might related to small intertrial intervals, the selection of the hemisphere (i.e., dominant vs. ipsilateral) examined in analyses (104) or the criteria used to classify participants as treatment-refractory (105).…”

Section: Lici In Patients With Epilepsymentioning

confidence: 63%

A Systematic Review of Long-Interval Intracortical Inhibition as a Biomarker in Neuropsychiatric Disorders

et al. 2021

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Long-interval intracortical inhibition (LICI) is a paired-pulse transcranial magnetic stimulation (TMS) paradigm mediated in part by gamma-aminobutyric acid receptor B (GABAB) inhibition. Prior work has examined LICI as a putative biomarker in an array of neuropsychiatric disorders. This review conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) sought to examine existing literature focused on LICI as a biomarker in neuropsychiatric disorders. There were 113 articles that met the inclusion criteria. Existing literature suggests that LICI may have utility as a biomarker of GABAB functioning but more research with increased methodologic rigor is needed. The extant LICI literature has heterogenous methodology and inconsistencies in findings. Existing findings to date are also non-specific to disease. Future research should carefully consider existing methodological weaknesses and implement high-quality test-retest reliability studies.

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Section: Lici In Patients With Epilepsymentioning

confidence: 63%

A Systematic Review of Long-Interval Intracortical Inhibition as a Biomarker in Neuropsychiatric Disorders

et al. 2021

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“…The implication of the inactivation of GABAB receptors is attested by the fact that blockade of these receptors increased the frequency of spontaneous epileptiform discharges recorded extracellularly (Karlsson et al, 1992) and that their activation exerted a suppressing effect on different types of epileptiform discharges from hippocampal neurons. Furthermore, GABAB receptor agonists have been shown to diminish seizure activity in an animal model (Joshi et al, 2016).…”

Section: Discussionmentioning

confidence: 99%