Targeting the gut-brain axis for therapeutic adherence in patients with inflammatory bowel disease: a review on the role of psychotherapy

Gravina, Antonietta Gerarda; Pellegrino, Raffaele; Palladino, Giovanna; Mazzarella, Chiara; Federico, Pierluigi; Arboretto, Giusi; D'Onofrio, R.; Olivieri, Simone; Zagaria, Giuseppe; Durante, Tommaso; Federico, Alessandro

doi:10.1080/27706710.2023.2181101

Cited by 10 publications

(9 citation statements)

References 98 publications

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“… 64 The authors found few studies in the field with the evidence suggesting a possible helpful impact on MA from (cognitive-behavioural) psychotherapy-based interventions but concluded that further studies are needed to obtain more definitive evidence. 64 …”

Section: Discussionmentioning

confidence: 99%

Improving Medication Adherence Levels in Inflammatory Bowel Disease (IBD) Patients: A Narrative Evidence-Based Review

Amiesimaka,

Aluzaite,

Braund

et al. 2024

PPA

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Inflammatory bowel disease (IBD) management is typified by a long-term medication regimen which can comprise multiple medications prescribed in different combinations, doses, frequencies, and with various administration routes. This complexity can make medication adherence (MA) – patients taking their medications per the prescription – for patients with IBD a challenge. The research corpus contains diverse interventions aimed at improving MA in patients with IBD. Therefore, to condense the evidenced strategies for ease of reference, this narrative evidence-based review broadly outlines the patient-level interventions reported. The interventions are grouped as educational, behavioural, cognitive-behavioural, and multicomponent. They, however, present mixed results as to their efficacy at improving MA, with those employing combined approaches being the most promising. This reflects the reality that MA is impacted by multiple factors encompassing those pertaining to the patient, disease, therapy, patients’ socioeconomic status, and health system. Hence, the most ideal interventions would likely be multifaceted patient-level interventions alongside policy/system-level strategies, to maximise the potential for successfully improving patients’ MA. These findings might have been impacted by the heterogeneity of the studies in terms of the method of MA assessment, duration of interventions, and more besides.

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Section: Discussionmentioning

confidence: 99%

Improving Medication Adherence Levels in Inflammatory Bowel Disease (IBD) Patients: A Narrative Evidence-Based Review

Amiesimaka,

Aluzaite,

Braund

et al. 2024

PPA

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“…Thus, neuromodulators and gut-brain behavioral therapies are recommended in IBS guidelines ( 50 ), but it is worth noting that trials involving these treatments have shown disappointing results in patients with IBD ( 50 – 52 ). Few studies in the literature have focused on the specific role of psychotherapy in enhancing therapeutic adherence among patients with IBD ( 53 ). In one trial comparing IBS-TSs in patients with and without IBD, hypnotherapy did not yield better responses than standard drug therapy ( 51 ).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease is causally related to irritable bowel syndrome: a bidirectional two-sample Mendelian randomization study

Lin

et al. 2023

Front. Med.

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IntroductionInflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are lifelong digestive diseases that severely impact patients’ quality of life. The existence of a causal association between IBS and IBD remains unclear. This study aimed to determine the direction of causality between IBD and IBS by quantifying their genome-wide genetic associations and performing bidirectional two-sample Mendelian randomization (MR) analyses.MethodsGenome-wide association studies (GWAS) among a predominantly European patient cohort identified independent genetic variants associated with IBS and IBD. Two separate databases (a large GWAS meta-analysis and the FinnGen cohort) for both IBS and IBD were consulted to retrieve statistics on instrument-outcome associations. MR analyses included inverse-variance-weighted, weighted-median, MR-Egger regression, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) methods, and sensitivity analyses were performed. The MR analyses were carried out for each outcome data, followed by a fixed-effect meta-analysis.ResultsGenetically predicted IBD was associated with an increased risk of IBS. Odds ratios (95% confidence intervals) for samples of 211,551 (17,302 individuals with IBD), 192,789 (7,476 Crohn’s disease cases), and 201,143 (10,293 ulcerative colitis cases) individuals were 1.20 (1.00, 1.04), 1.02 (1.01, 1.03), and 1.01 (0.99, 1.03), respectively. After outlier correction using MR-PRESSO, the odds ratio for ulcerative colitis was 1.03 (1.02, 1.05) (p = 0.001). However, an association between genetically influenced IBS and IBD was not identified.DiscussionThis study confirms that IBD is causally related to IBS, which may interfere with the diagnosis and treatment of both diseases.

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“…The different psychological techniques applied to IBD include cognitive behavioural therapy (CCBT), social support, stress management, and targeted techniques[ 98 , 99 ]. Many studies that have weighed the impact of psychology on managing IBD have also included remotely performed treatments.…”

Section: Special Applicationsmentioning

confidence: 99%

Telemedicine in inflammatory bowel diseases: A new brick in the medicine of the future?

Gravina,

Pellegrino,

Durante

et al. 2023

World J Methodol

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The documentation of psychological trauma is obviously a challenge to clinicians while they are diving deep into remote events related to their clients or patients. The potential role of psychological trauma in the early developmental stages, and even the existence of adverse childhood experiences, is important to prove, yet it is difficult to do so. A diverse range of methods have been applied, all of which presumably benchmark a big therapeutic step; however, these enthusiastic methods frequently do not last for long. While hypnosis supporters, Freudian and Neo-Freudian disciples can be acute enough to enhance and uncover suppressed memories, modern psychiatry relies mostly on diversely structured interviews. Functional magnetic resonance and its related subtleties might help, but the questions that remain unanswered are numerous and confusing. Connecting early experiences with long-term memory while identifying psychological trauma its importance for the individual’s growth trajectory; thus, it remains an intriguing issue.

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Targeting the gut-brain axis for therapeutic adherence in patients with inflammatory bowel disease: a review on the role of psychotherapy

Cited by 10 publications

References 98 publications

Improving Medication Adherence Levels in Inflammatory Bowel Disease (IBD) Patients: A Narrative Evidence-Based Review

Improving Medication Adherence Levels in Inflammatory Bowel Disease (IBD) Patients: A Narrative Evidence-Based Review

Inflammatory bowel disease is causally related to irritable bowel syndrome: a bidirectional two-sample Mendelian randomization study

Telemedicine in inflammatory bowel diseases: A new brick in the medicine of the future?

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