Targeting the JAK2/STAT3 signaling pathway with natural plants and phytochemical ingredients: A novel therapeutic method for combatting cardiovascular diseases

Guo, Bing; Yu, Yunfeng; Wang, Min; Li, Ronghui; He, Xuan; Tang, Siqin; Liu, Qili; Mao, Yilin

doi:10.1016/j.biopha.2024.116313

Cited by 3 publications

(2 citation statements)

References 129 publications

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“…Many studies described that phytochemical components originated from vegetables, seeds, fruits, and different parts of trees, e.g., leaves and roots, are having several therapeutic applications for various diseases based on their action mechanisms in both animal and human subjects focusing on cardiovascular diseases [ 184 ]. We also discuss in the present review how the natural compounds modulate their molecular targets and signal transduction mechanisms in cardiovascular diseases including inflammation ischemia/reperfusion-induced injury as oxidative mediated pathogenesis, providing indications for their use in further clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Evolving Strategies for Use of Phytochemicals in Prevention and Long-Term Management of Cardiovascular Diseases (CVD)

Haines,

Cowan,

Tosaki

2024

IJMS

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This report describes major pathomechanisms of disease in which the dysregulation of host inflammatory processes is a major factor, with cardiovascular disease (CVD) as a primary model, and reviews strategies for countermeasures based on synergistic interaction between various agents, including drugs and generally regarded as safe (GRAS) natural medical material (NMM), such as Ginkgo biloba, spice phytochemicals, and fruit seed flavonoids. The 15 well-defined CVD classes are explored with particular emphasis on the extent to which oxidative stressors and associated ischemia-reperfusion tissue injury contribute to major symptoms. The four major categories of pharmaceutical agents used for the prevention of and therapy for CVD: statins, beta blockers (β-blockers), blood thinners (anticoagulants), and aspirin, are presented along with their adverse effects. Analyses of major cellular and molecular features of drug- and NMM-mediated cardioprotective processes are provided in the context of their development for human clinical application. Future directions of the evolving research described here will be particularly focused on the characterization and manipulation of calcium- and calcineurin-mediated cascades of signaling from cell surface receptors on cardiovascular and immune cells to the nucleus, with the emergence of both protective and pathological epigenetic features that may be modulated by synergistically-acting combinations of drugs and phytochemicals in which phytochemicals interact with cells to promote signaling that reduces the effective dosage and thus (often) toxicity of drugs.

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Section: Discussionmentioning

confidence: 99%

Evolving Strategies for Use of Phytochemicals in Prevention and Long-Term Management of Cardiovascular Diseases (CVD)

Haines,

Cowan,

Tosaki

2024

IJMS

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“…By improving the phytochemical properties of plants, in addition to increasing their antimicrobial properties, nanoparticles with highly desirable purity and concentration can be synthesized. These phytochemicals have properties in plants Prevention of Diseases [10,25]. Plants produce phytochemicals to protect themselves.…”

Section: Introductionmentioning

confidence: 99%

Halpeh Extract-Derived Gold Nanoparticles: A Dual Force Against Microbes and for Phytochemical Enhancement

Dahaz,

Asadi,

Lashgari

2024

Preprint

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The increasing resistance of pathogenic microorganisms to conventional antibiotics has led to a growing interest in alternative antimicrobial agents. In this study, the antimicrobial activity (antibacterial and antifungal) of aqueous and methanolic extracts of Halpeh plant and gold nanoparticles synthesized using the extract of this plant was investigated. Additionally, the effect of different concentrations of synthesized gold nanoparticles on the phytochemical properties (antioxidant and reducing ability) of Halpeh plant extract was examined. The results of UV-Vis (Ultraviolet-Visible Spectroscopy), XRD (X-Ray Diffraction Analysis), TEM (Transmission Electron Microscopy), SEM (Scanning Electron Microscopy), and FTIR (Fourier Transform Infrared Spectroscopy) tests on gold nanoparticles confirmed their synthesis. SEM and TEM images showed that the gold nanoparticles were spherical in shape with an average size of 22.89 nm. According to the results, the methanolic extract exhibited significantly higher antibacterial and antifungal activity compared to the aqueous extract, with the maximum inhibition zone diameters observed for Escherichia coli (14 mm) and Aspergillus niger (15 mm). Moreover, the antimicrobial activity of gold nanoparticles showed that these nanoparticles have relatively good ability to inhibit gram-negative bacteria, with the largest inhibition zone diameters observed for Escherichia coli (18 mm) and Aspergillus niger (20 mm). The antioxidant and reducing power activity (phenolic flavonoids content) of Halpeh plant extract treated with different concentrations of synthesized gold nanoparticles increased with increasing nanoparticle concentrations up to 60 ppm (IC50 = 9.94 µg/ml and reducing power = 16.85 mMFe2+/mg sample), and decreased at higher concentrations.

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Verapamil attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis via activating the JAK2/STAT3 signaling pathway

Zhao,

Huang,

Liu

et al. 2024

Biomedicine & Pharmacotherapy

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Targeting the JAK2/STAT3 signaling pathway with natural plants and phytochemical ingredients: A novel therapeutic method for combatting cardiovascular diseases

Cited by 3 publications

References 129 publications

Evolving Strategies for Use of Phytochemicals in Prevention and Long-Term Management of Cardiovascular Diseases (CVD)

Evolving Strategies for Use of Phytochemicals in Prevention and Long-Term Management of Cardiovascular Diseases (CVD)

Halpeh Extract-Derived Gold Nanoparticles: A Dual Force Against Microbes and for Phytochemical Enhancement

Verapamil attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis via activating the JAK2/STAT3 signaling pathway

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