2015
DOI: 10.1111/nyas.12953
|View full text |Cite
|
Sign up to set email alerts
|

Targeting the lysosome in cancer

Abstract: Lysosomes are membrane-bound intracellular organelles that receive macromolecules delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. Over the last decade, advances in lysosome research have established a broad role for the lysosome in the pathophysiology of disease. In this review, we highlight the recent discoveries in lysosome biology, with an emphasis on their implications for cancer therapy. We focus on targeting the lysosome in cancer by exploring lysosomal biogenesis and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
226
0

Year Published

2016
2016
2024
2024

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 243 publications
(228 citation statements)
references
References 79 publications
2
226
0
Order By: Relevance
“…Second, deletion of autophagy genes in the setting of certain mouse models can result in the initiation of neoplasia. The initial identification of this phenotype was in Beclin1 (ATG6 ortholog) heterozygous mice, whereby these mice developed various neoplasms (Qu et al, 2003; Yue et al, 2003). An important aspect to note is that in this case autophagy was only partly attenuated as a functional copy of Beclin1 was intact in the mice.…”
Section: Autophagy and Cancermentioning
confidence: 99%
“…Second, deletion of autophagy genes in the setting of certain mouse models can result in the initiation of neoplasia. The initial identification of this phenotype was in Beclin1 (ATG6 ortholog) heterozygous mice, whereby these mice developed various neoplasms (Qu et al, 2003; Yue et al, 2003). An important aspect to note is that in this case autophagy was only partly attenuated as a functional copy of Beclin1 was intact in the mice.…”
Section: Autophagy and Cancermentioning
confidence: 99%
“…As CQ and HCQ have been used in patients for many years for a variety of indications, testing this as a therapeutic approach in cancer patients is feasible and currently ongoing[2,183]. As these agents act on the lysosome by inhibiting lysosomal acidification they inhibit the late stages of autophagy at the level of autophagosome maturation and cargo degradation[183].…”
Section: Pro-tumorigenic Functions Of Autophagymentioning
confidence: 99%
“…As these agents act on the lysosome by inhibiting lysosomal acidification they inhibit the late stages of autophagy at the level of autophagosome maturation and cargo degradation[183]. In addition, these drugs may have other non-autophagy specific therapeutic effects as they block other processes that depend on lysosomal activity.…”
Section: Pro-tumorigenic Functions Of Autophagymentioning
confidence: 99%
“…The Na + /H + exchanger has also been associated with extracellular acidification and cancer cell invasion [36]. Another intriguing aspect of lysosomes is their ability to secrete contents out of the cell by fusing with the plasma membrane [4, 37]. For example, cells can expel ATP to the extracellular space with this secretory pathway to mediate cellular signaling through ATP receptors [38, 39].…”
Section: Lysosomes and Cancer Progressionmentioning
confidence: 99%
“…Bafilomycin A1 has also been shown to prevent autophagosome formation by activation of mTOR signaling, suggesting that it may target both the early and late stages of autophagy [89]. This impairment is mediated by dissociation of the Beclin1-Vps34 complex and encourages Bcl-2 interaction to drive autophagy inhibition and apoptotic cell death [37]. Interestingly, Bafilomycin has also been shown to engage the mitochondria and induce translocation of apoptosis inducing factor to the nucleus and provoke caspase-independent apoptosis [90].…”
Section: Drugs That Target the Lysosomementioning
confidence: 99%