Targeting the PANoptosome with 3,4-Methylenedioxy-β-Nitrostyrene, Reduces PANoptosis and Protects the Kidney against Renal İschemia-Reperfusion Injury

Uysal, Erdal; Dokur, Mehmet; Küçükdurmaz, Fatih; Altınay, Serdar; Polat, Sait; Batçıoğlu, Kadir; Sezgın, Efe; Erçakallı, Tuğçe Sapmaz; Yaylali, Aslı; Yilmaztekin, Yakup; Çetin, Zafer; Saygılı, İlker; Barut, Osman; Kazımoğlu, Hatem; Maralcan, Göktürk; Koç, Suna; Guney, Turkan; Eser, Nadire; Sökücü, Mehmet; Dokur, Sema Nur

doi:10.1080/08941939.2022.2128117

Cited by 15 publications

(7 citation statements)

References 57 publications

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“… 76 The occurrence of PANoptosis has also been found in cerebral ischemia or ischemia-reperfusion injury, 77 indicating that PANoptosis plays an important role in ischemia-reperfusion injury. 78 , 79 In addition, an in vivo and in vitro experiment found that PANoptosis occurred in retinal neurons under ischemia-reperfusion injury from morphological characteristics to gene level, specifically manifested in significantly increased cleaved caspase-3, NLRP3, cleaved caspase-1 (p20), GSDMD, phosphorylated RIP3 and MLKL, and high expression of pro-apoptotic protein BAX and proinflammatory cytokines IL-1β (p17), IL-18 (p22). However, the expression of these molecules decreased after inhibition of GSDMD or administration of necroptosis inhibitors.…”

Section: Panoptosis and Diseasesmentioning

confidence: 99%

PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis

Shi¹,

Cao²,

Wang³

et al. 2023

JIR

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PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone. The interaction between pyroptosis, apoptosis and necroptosis is involved in PANoptosis. In this review, from the perspective of PANoptosis, we focus on the relationship between pyroptosis, apoptosis and necroptosis, the key molecules in the process of PANoptosis and the formation of PANoptosome, as well as the role of PANoptosis in diseases. We aim to understand the mechanism of PANoptosis and provide a basis for targeted intervention of PANoptosis-related molecules to treat human diseases.

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Section: Panoptosis and Diseasesmentioning

confidence: 99%

PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis

Shi¹,

Cao²,

Wang³

et al. 2023

JIR

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“…129 Targeting the PANoptosome with 3,4-methylene dioxyβ-nitrostyrene administrated before the reperfusion enables to reduce PANoptosis and protect the kidney against I/R injury. 130…”

Section: Ischemia/reperfusion (I/r) Injurymentioning

confidence: 99%

“…Evidence from cell and rodent experiments suggests that pyroptosis, apoptosis, and necroptosis simultaneously occur in cerebral I/R injury 129 . Targeting the PANoptosome with 3,4‐methylenedioxy‐β‐nitrostyrene administrated before the reperfusion enables to reduce PANoptosis and protect the kidney against I/R injury 130 …”

Section: Multifaceted Roles and Therapeutic Potential Of Panoptosis I...mentioning

confidence: 99%

PANoptosis: Mechanisms, biology, and role in disease

Sun,

Yang,

Meng

et al. 2023

Immunological Reviews

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SummaryCell death can be executed through distinct subroutines. PANoptosis is a unique inflammatory cell death modality involving the interactions between pyroptosis, apoptosis, and necroptosis, which can be mediated by multifaceted PANoptosome complexes assembled via integrating components from other cell death modalities. There is growing interest in the process and function of PANoptosis. Accumulating evidence suggests that PANoptosis occurs under diverse stimuli, for example, viral or bacterial infection, cytokine storm, and cancer. Given the impact of PANoptosis across the disease spectrum, this review briefly describes the relationships between pyroptosis, apoptosis, and necroptosis, highlights the key molecules in PANoptosome formation and PANoptosis activation, and outlines the multifaceted roles of PANoptosis in diseases together with a potential for therapeutic targeting. We also discuss important concepts and pressing issues for future PANoptosis research. Improved understanding of PANoptosis and its mechanisms is crucial for identifying novel therapeutic targets and strategies.

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“…PANoptosome promotes FADD–CASP8-dependent apoptosis and necroptosis and activates the pyrin domain in NLRP3 inflammasome via RIPK3-mediated phosphorylation of MLKL for initiating pyroptosis 21 . PANoptosis is involved in several other diseases, such as sepsis, systemic inflammatory diseases, multiple organ failure, cancer, novel coronavirus infection, and cytokine shock in addition to infectious diseases 22 – 24 . These diseases involve severe systemic inflammatory syndromes with elevated levels of circulating pro-inflammatory cytokines or cytokine storms in the patient 22 .…”

Section: Introductionmentioning

confidence: 99%

PANoptosis-like death in acute-on-chronic liver failure injury

Ye,

Wang,

Chen

et al. 2024

Sci Rep

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The pathogenesis of Acute-on-chronic liver failure (ACLF) involves several forms of cell death, such as pyroptosis, apoptosis, and necroptosis, which consist of PANoptosis. To explore PANoptosis as a regulated cell death pathway in ACLF. Firstly, a bioinformatic strategy was used to observe the role of the PANoptosis pathway in ACLF and identify differentially expressed genes related to PANoptosis. Enrichment analysis showed that PANoptosis-related pathways were up-regulated in ACLF. We screened out BAX from the intersection of pyroptosis, apoptosis, necroptosis, and DEGs. Secondly, we screened articles from literature databases related to PANoptosis and liver failure, and specific forms of PANoptosis were reported in different experimental models in vitro and in vivo. Secondly, we established a model of ACLF using carbon tetrachloride-induced liver fibrosis, followed by D-galactosamine and lipopolysaccharide joint acute attacks. A substantial release of inflammatory factors(IL-6, IL-18, TNFα, and IFNγ) and the key proteins of PANoptosis (NLRP3, CASP1, GSDMD, BAX, CASP8, CASP3, CASP7, and MLKL) were detected independently in the ACLF rats. Finally, we found that combining TNF-α/INF-γ inflammatory cytokines could induce L02 cells PANoptosis. Our study highlighted the potential role of ACLF and helps drug discovery targeting PANoptosis in the future.

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Targeting the PANoptosome with 3,4-Methylenedioxy-β-Nitrostyrene, Reduces PANoptosis and Protects the Kidney against Renal İschemia-Reperfusion Injury

Cited by 15 publications

References 57 publications

PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis

PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis

PANoptosis: Mechanisms, biology, and role in disease

PANoptosis-like death in acute-on-chronic liver failure injury

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