2022
DOI: 10.3390/nu14204414
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Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients

Abstract: Platelet-activating factor (PAF) is a lipid mediator that interacts with its receptor (PAF-R) to carry out cell signalling. However, under certain conditions the binding of PAF to PAF-R leads to the activation of pro-inflammatory and prothrombotic pathways that have been implicated in the onset and development of atherosclerotic cardiovascular diseases (CVD) and inflammatory diseases. Over the past four decades, research has focused on the identification and development of PAF-R antagonists that target these i… Show more

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Cited by 24 publications
(17 citation statements)
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“…These include phosphoglycerides, leukotrienes, lysophospholipids, and the phospholipid platelet activating factor (PAF). PAF binds the PAF receptor and triggers downstream activation, thereby regulating processes such as the immune response, cell proliferation and apoptosis, making it an important mediator of these downstream signalling events [ 108 ].…”
Section: The Role Of Phospholipid Subclasses and Their Biological Fun...mentioning
confidence: 99%
“…These include phosphoglycerides, leukotrienes, lysophospholipids, and the phospholipid platelet activating factor (PAF). PAF binds the PAF receptor and triggers downstream activation, thereby regulating processes such as the immune response, cell proliferation and apoptosis, making it an important mediator of these downstream signalling events [ 108 ].…”
Section: The Role Of Phospholipid Subclasses and Their Biological Fun...mentioning
confidence: 99%
“…Platelet-activating factor (PAF) is a phospholipid mediator of inflammation that also induces platelet activation and aggregation. PAF functions by binding to the PAF receptor (PAF-R), a G-protein coupled receptor (GPCR) located on cells involved in immune function [9,10]. The consumption of foods or nutraceuticals rich in bioactive lipids (dietary polar lipids) that target platelet signalling pathways such as thrombin and PAF may be beneficial against inflammatory diseases [10].…”
Section: Introductionmentioning
confidence: 99%
“…PAF functions by binding to the PAF receptor (PAF-R), a G-protein coupled receptor (GPCR) located on cells involved in immune function [9,10]. The consumption of foods or nutraceuticals rich in bioactive lipids (dietary polar lipids) that target platelet signalling pathways such as thrombin and PAF may be beneficial against inflammatory diseases [10]. However, the research is still at a preliminary stage to date, which necessitates the need for further study.…”
Section: Introductionmentioning
confidence: 99%
“…PAF is an ether-linked glycerophospholipid that is one of the most potent inflammatory mediators in the body that is active in nanomolar concentrations and is closely implicated in all stages of atherosclerosis [ 9 ]. PAF is produced by numerous cells such as platelets, endothelial cells, and leukocytes and triggers an inflammatory cascade through the act of binding to the G-protein coupled PAF receptor [ 10 , 11 ]. PAF is involved in the early stages of atherosclerosis by the mediation of adhesion of monocytes to the endothelium and increasing endothelial permeability, allowing low-density lipoproteins (LDL) and monocytes to migrate into the intima [ 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%