Targeting the tumor microenvironment in primary central nervous system lymphoma: Implications for prognosis

Shi, Han; Sun, Xuefei; Wu, Yuchen; Cui, Qu; Sun, Shengjun; Ji, Nan; Liu, Yuanbo

doi:10.1016/j.jocn.2024.04.009

Cited by 1 publication

(1 citation statement)

References 119 publications

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“…PCNSL follows an aggressive clinical course, with DLBCL being the most common histological type in around 90% of cases [ 141 ]. The comparative analysis between PCNSL and DLBCL suggests that PCNSL is more likely to be an immunologically deficient tumour, with a reduced number of T cells alongside M2 polarised macrophages, endothelin B receptor, HLA depletion, PD-L1, and T cell immunoglobulin, and a mucin-domain containing-3 (TIM-3) [ 142 ]. Use of flow cytometry showed the presence of both M2 and M1 macrophages.…”

Section: Role Of the Tumour Microenvironment In Rare B Cell Lymphomasmentioning

confidence: 99%

Tumour Microenvironment: The General Principles of Pathogenesis and Implications in Diffuse Large B Cell Lymphoma

Sinkarevs,

Strumfs,

Volkova

et al. 2024

Cells

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Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma worldwide, constituting around 30–40% of all cases. Almost 60% of patients develop relapse of refractory DLBCL. Among the reasons for the therapy failure, tumour microenvironment (TME) components could be involved, including tumour-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), tumour-associated neutrophils (TANs), cancer-associated fibroblasts (CAFs), and different subtypes of cytotoxic CD8+ cells and T regulatory cells, which show complex interactions with tumour cells. Understanding of the TME can provide new therapeutic options for patients with DLBCL and improve their prognosis and overall survival. This review provides essentials of the latest understanding of tumour microenvironment elements and discusses their role in tumour progression and immune suppression mechanisms which result in poor prognosis for patients with DLBCL. In addition, we point out important markers for the diagnostic purposes and highlight novel therapeutic targets.

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Section: Role Of the Tumour Microenvironment In Rare B Cell Lymphomasmentioning

confidence: 99%

Tumour Microenvironment: The General Principles of Pathogenesis and Implications in Diffuse Large B Cell Lymphoma

Sinkarevs,

Strumfs,

Volkova

et al. 2024

Cells

View full text Add to dashboard Cite

show abstract

Targeting the tumor microenvironment in primary central nervous system lymphoma: Implications for prognosis

Cited by 1 publication

References 119 publications

Tumour Microenvironment: The General Principles of Pathogenesis and Implications in Diffuse Large B Cell Lymphoma

Tumour Microenvironment: The General Principles of Pathogenesis and Implications in Diffuse Large B Cell Lymphoma

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