Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones

Synthetic Approaches to Polyhydroxy Indolizidines and Related Azabicyclic Scaffolds

“…In order to further exploit the existing functionality and to provide access to more versatile scaffolds, we converted an epimeric mixture of 12 to the corresponding ketone, which was transformed smoothly to the enol triflate (13). This potential Suzuki reaction coupling partner was deoxygenated in the presence of Pd(PPh 3 ) 4 and n-Bu 3 SnH 17 to the olefin (14). Deprotection under standard conditions led to the unsaturated indolizidine triol (15).…”

Structure‐Based Organic Synthesis of Drug Prototypes: A Personal Odyssey

“…[157] Key steps in the synthesis of these indolizidinones were the stereocontrolled introduction of hydroxy and amino groups at tertiary carbon atoms via lactam enolate chemistry. [155][156][157][158] Synthetic approaches to indolizidinones and related bicyclic lactam carboxylic acids have been reported by us and various other research groups.…”

“…Further synthetic efforts led to the aminoindolizidinone 89, which showed an inhibition value of IC 50 = 4.7 nm. [156] The epimeric amine 90 was 500-fold less active, while other analogues designed based on modeling of X-ray data were of variable activity. [157] Key steps in the synthesis of these indolizidinones were the stereocontrolled introduction of hydroxy and amino groups at tertiary carbon atoms via lactam enolate chemistry.…”

Heterocycles Containing a Ring‐Junction Nitrogen

“…Other important compounds include A-289 099 (116), an orally active antimitotic agent against various cancer cell lines that acts through inhibition of tubulin polymerization by binding at the colchicine site [60]. A series of indolizidinones of general structure 117 has been designed and synthesized to evaluate their inhibitory effect on Factor VIIA (FVIIa) in comparison to thrombin [61]. The bicyclic 2-pyridone derivative 118 has been described as a 3CP (human rhinovirus 3C protease) inhibitor and exhibited potent antirhinoviral activity in cell cultures when tested against different human rhinovirus (HRV) serotypes [62].…”