2024
DOI: 10.3324/haematol.2023.283647
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Targeting TNF/IL-17/MAPK pathway in h<i>E2A-PBX1</i> leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842

Haiping Luo,
Qiqi Li,
Jiaxin Hong
et al.

Abstract: t(1;19)(q23;p13) is one of the most common translocation genes in childhood acute lymphoblastic leukemia (ALL) and is also present in acute myeloid leukemia (AML) and mixed-phenotype acute leukemia (MPAL). This translocation results in the formation of the oncogenic E2A-PBX1 fusion protein, which contains a trans-activating domain from E2A and a DNA-binding homologous domain from PBX1. Despite its clear oncogenic potential, the pathogenesis of E2A-PBX1 fusion protein is not fully understood (especially in leuk… Show more

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