Targeting transitioning lung monocytes/macrophages as treatment strategies in lung disease related to environmental exposures
Aaron D. Schwab,
Todd A. Wyatt,
Grace Moravec
et al.
Abstract:Background
Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monocytes/macrophages, yet their cellular role remains unclear.
Methods
CCR2 RFP+ mice were intratracheally instilled with high concentration ODE (25%), LPS (10µg), or gram-positive peptidoglycan (PGN, 100µg) for monocyte/macrophage cell-trafficking studies. CCR2 knockout (KO) mice and administrat… Show more
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