Targeting tumor‐associated macrophages: A potential treatment for solid tumors

Chen, Yi-Bing; Jin, Huan; Song, Yucen; Huang, Ting; Cao, Jun; Tang, Qing; Zou, Zhengzhi

doi:10.1002/jcp.30139

Cited by 48 publications

(46 citation statements)

References 187 publications

(272 reference statements)

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“…Increased TAM infiltration correlates with an inert response to cancer treatment and poor prognosis in multiple cancer models. 28 Hence, targeting TAMs is a potential and promising strategy for cancer immunotherapies. Immunotherapeutic strategies fall into three major categories: (1) decreasing the TAM population, (2) promoting macrophage phagocytic activity, and (3) reprogramming TAMs to an antitumor M1 phenotyope ( Figure 1 ).…”

Section: Tams In Cancer Immunotherapymentioning

confidence: 99%

Molecular imaging of tumor-associated macrophages in cancer immunotherapy

Wang

Zhang

et al. 2022

Ther Adv Med Oncol

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Tumor-associated macrophages (TAMs), the most abundant inflammatory cell group in the tumor microenvironment, play an essential role in tumor immune regulation. The infiltration degree of TAMs in the tumor microenvironment is closely related to tumor growth and metastasis, and TAMs have become a promising target in tumor immunotherapy. Molecular imaging is a new interdisciplinary subject that combines medical imaging technology with molecular biology, nuclear medicine, radiation medicine, and computer science. The latest progress in molecular imaging allows the biological processes of cells to be visualized in vivo, which makes it possible to better understand the density and distribution of macrophages in the tumor microenvironment. This review mainly discusses the application of targeting TAM in tumor immunotherapy and the imaging characteristics and progress of targeting TAM molecular probes using various imaging techniques.

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Section: Tams In Cancer Immunotherapymentioning

confidence: 99%

Molecular imaging of tumor-associated macrophages in cancer immunotherapy

Wang

Zhang

et al. 2022

Ther Adv Med Oncol

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“…Since expression of PD-L1 is associated with poor prognosis, a clinical trial with immune checkpoint immunotherapy seems warranted. Moreover, since the neoplastic cells and osteoclast-like giant cells are surrounded by CD163 + TAM2 that promote survival and proliferation of neoplastic cells ( 30 ), UC-OGC may be investigated as a model for testing therapies that block or “re-educate” that macrophage population ( 76 , 77 ). Whole exome sequencing might further provide potential treatment strategies for UC-OGC.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

et al. 2021

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Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of the pancreas, the WHO Classification distinguishes undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) from plain undifferentiated carcinoma since there are a few histopathological and clinical differences. UC-OGC was initially thought to be associated with worse prognosis compared to invasive ductal pancreatic adenocarcinoma, since it is often unresectable at diagnosis and tends to recur rapidly even if completely resected. When true UC-OGGs are carefully dissected out from other anaplastic carcinomas, it becomes, however, clear that UC-OGCs do have more indolent behavior, especially the pure UC-OGCs. This mini-review summarizes the current knowledge on UC-OGC.

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“…Communication within the TME is bidirectional because TAM signaling is involved in tumor initiation, accelerated disease progression and metastasis [ 16 ]. There is increasing evidence that TAMs influence various aspects of tumor progression such as tumor initiation, tumor angiogenesis, immunosuppression, invasion, and metastasis through the release of cytokines or growth factors into the TME [ 15 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

Zhu

et al. 2021

Exp Hematol Oncol

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Macrophages are heterogeneous cells that present as different functional phenotypes due to their plasticity. They can be classified into two categories, namely M1- and M2-like macrophages, which are involved in processes as diverse as anti-tumor activity and immunosuppressive tumor promotion. Tumor-associated macrophages (TAMs) are defined as being of an M2-type and are considered as the active component in tumor microenvironment. TAMs are involved in multiple processes of tumor progression through the expression of cytokines, chemokines, growth factors, protein hydrolases and more, which lead to enhance tumor cell proliferation, angiogenesis, and immunosuppression, which in turn supports invasion and metastasis. It is assumed that the abundance of TAMs in major solid tumors is correlated to a negative patient prognosis. Because of the currently available data of the TAMs’ role in tumor development, these cells have emerged as a promising target for novel cancer treatment strategies. In this paper, we will briefly describe the origins and types of TAMs and will try to comprehensively show how TAMs contribute to tumorigenesis and disease progression. Finally, we will present the main TAM-based therapeutic strategies currently available.

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Targeting tumor‐associated macrophages: A potential treatment for solid tumors

Cited by 48 publications

References 187 publications

Molecular imaging of tumor-associated macrophages in cancer immunotherapy

Molecular imaging of tumor-associated macrophages in cancer immunotherapy

Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

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