Targeting tumor associated macrophages in hepatocellular carcinoma

Xu, Wenqian; Cheng, Yuliang; Guo, Yahui; Yao, Weirong; He, Qian

doi:10.1016/j.bcp.2022.114990

Cited by 21 publications

(15 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous study has reported that macrophages is innate immune cell that plays a key role in early neoplastic transformation and metastatic progression [18]. It has been indicated that M2 macrophages can promote angiogenesis, metastasis, and, most signi cantly, immunosuppression of hepatocellular carcinoma cells [19]. Consistence with that, our study showed that SPATS2 overexpression with high macrophage cell in ltration patients had a worse overall survival, especially macrophage M2 cell.…”

Section: Discussionsupporting

confidence: 72%

SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma

Jia

Lin

Deng

et al. 2022

Preprint

View full text Add to dashboard Cite

The spermatogenesis associated serine rich 2 (SPATS2) is a member of RNA-binding protein in which the abnormal expression is linked with carcinogenesis in serval types of cancer. However, there is no systematic study on the differential expression, prognostic significance, epigenetic regulation, immune infiltration of SPATS2 in HCC. In the present study, we investigated the expression, prognosis, epigenetic regulation, and immune cell infiltration of SPATS2 in HCC. We found that the elevated expression of SPATS2 was unfavorably associated with the clinical pathological stage and prognosis. Functional enrichment analysis revealed that SPATS2 associated with cell cycle, apoptosis and cancer cell metastasis processes in HCC. Our results confirmed that knockdown of SPATS2 will affect cell cycle, apoptosis and invasion of HCC cell lines. Moreover, the expression of SPATS2 is upregulated by epigenetic regulation, including DNA methylation, m6A and histone modification in HCC. In addition, SPATS2 expression was positively correlated with immune cell or gene markers of immune infiltration in HCC. Taken together, our data demonstrated that SPATS2 was associated with progression and immune infiltration, and could serve as a prognostic biomarker for HCC. In conclusion, these results highlight the potential of SPATS2 to be used as a therapeutic target for HCC.

show abstract

Section: Discussionsupporting

confidence: 72%

SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma

Jia

Lin

Deng

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Within the tumor, macrophages could affect the development and progression of HCC. Xu et al discussed the possible approaches for tumor-associated macrophage (TAMs) therapy as potential targets for HCC treatment [50]. T cell is the most numerous type with complex functions in lymphocytes [51].…”

Section: Discussionmentioning

confidence: 99%

Cell Pair Algorithm-Based Immune Infiltrating Cell Signature for Improving Outcomes and Treatment Responses in Patients with Hepatocellular Carcinoma

Zhang

Xie

et al. 2023

Cells

View full text Add to dashboard Cite

Background: Immune interactions play important roles in the regulation of T cells’ cytotoxic function, further impacting the anti-tumor efficacy of immunotherapy. A comprehensive analysis of immune cell types in HCC and immune-cell-related signatures predicting prognosis and monitoring immunotherapy efficacy is still absent. Methods: More than 1,300 hepatocellular carcinomas (HCC) patients were collected from public databases and included in the present study. The ssGSEA algorithm was applied to calculate the infiltration level of 28 immunocyte subpopulations. A cell pair algorithm was applied to construct an immune-cell-related prognostic index (ICRPI). Survival analyses were performed to measure the survival difference across ICRPI risk groups. Spearman’s correlation analyses were used for the relevance assessment. A Wilcoxon test was used to measure the expression level’s differences. Results: In this study, 28 immune subpopulations were retrieved, and 374 immune cell pairs (ICPs) were established, 38 of which were picked out by the least absolute shrinkage and selection operator (LASSO) algorithm. By using the selected ICPs, the ICRPI was constructed and validated to play crucial roles in survival stratification and dynamic monitoring of immunotherapy effect. We also explored several candidate drugs targeting ICRPI. A composite ICRPI and clinical prognostic index (ICPI) was then constructed, which achieved a more accurate estimation of HCC’s survival and is a better choice for prognosis predictions in HCC. Conclusions: In conclusion, we constructed and validated ICRPI based on the cell pair algorithm in this study, which might provide some novel insights for increasing the survival estimation and clinical response to immune therapy for individual HCC patients and contribute to the personalized precision immunotherapy strategy of HCC.

show abstract

“…Based on numerous research on mechanisms of TAMs affecting HCC, TAMs play an irreplaceable role in HCC, so it is considered meaningful and promising to treat HCC by targeting TAMs. As many drugs targeting TAMs are still in clinical trials at present, main mechanisms are to eliminate the existence of TAMs, block the recruitment of TAMs, reprogram the polarization of TAMs, regulate products of TAMs, and restore the phagocytic ability of TAMs 35 . TAMs can result in drug resistance in HCC, and hence targeting TAMs may alleviate drug resistance and improve the efficacy of anti‐tumor therapy (Table 1).…”

Section: Role Of Tams In Hccmentioning

confidence: 99%

The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review

Zhang,

Yu,

Zhao

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, with complex etiology and mechanism, and a high mortality rate. Tumor‐associated macrophages (TAMs) are an important part of the HCC tumor microenvironment. Studies in recent years have shown that TAMs are involved in multiple stages of HCC and are related to treatment and prognosis in HCC. The specific mechanisms between TAMs and HCC are gradually being revealed. This paper reviews recent advances in the mechanisms associated with TAMs in HCC, concentrating on an overview of effects of TAMs on drug resistance in HCC and the signaling pathways linked with HCC, providing clues for the treatment and prognosis determination of HCC.

show abstract

Targeting tumor associated macrophages in hepatocellular carcinoma

Cited by 21 publications

References 94 publications

SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma

SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma

Cell Pair Algorithm-Based Immune Infiltrating Cell Signature for Improving Outcomes and Treatment Responses in Patients with Hepatocellular Carcinoma

The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review

Contact Info

Product

Resources

About