Targeting Tumor Microenvironment: Effects of Chinese Herbal Formulae on Macrophage‐Mediated Lung Cancer in Mice

Xu, Fei; Cui, Weihong; Zhao, Zhengxiao; Gong, Wei; Wei, Ying; Liu, Jiaqi; Li, Mihui; Li, Qiuping; Yan, Chen‐Hua; Qiu, Jian; Liu, Baojun; Dong, Jingcheng

doi:10.1155/2017/7187168

Cited by 17 publications

(21 citation statements)

References 43 publications

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“…It is worth noting that CXCL12/CXCR4 and JAK2/ STAT3 are important molecules involved in M2 polarization. QRHX also reduces the expression of CXCL12/CXCR4 and the phosphorylation of JAK2/STAT3 in tumor tissues (175). These results also indicate that QRHX may induce the conversion of M2 type macrophages to M1 type macrophages, reducing tumor tissue angiogenesis.…”

Section: Inhibition Of Tumor Angiogenesismentioning

confidence: 63%

The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy

2020

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Tumor microenvironment (TME) is composed of tumor cells and surrounding non-tumor stromal cells, mainly including tumor associated macrophages (TAMs), endothelial cells, and carcinoma-associated fibroblasts (CAFs). The TAMs are the major components of non-tumor stromal cells, and play an important role in promoting the occurrence and development of tumors. Macrophages originate from bone marrow hematopoietic stem cells and embryonic yolk sacs. There is close crosstalk between TAMs and tumor cells. With the occurrence of tumors, tumor cells secrete various chemokines to recruit monocytes to infiltrate tumor tissues and further promote their M2-type polarization. Importantly, M2-like TAMs can in turn accelerate tumor growth, promote tumor cell invasion and metastasis, and inhibit immune killing to promote tumor progression. Therefore, targeting TAMs in tumor tissues has become one of the principal strategies in current tumor immunotherapy. Current treatment strategies focus on reducing macrophage infiltration in tumor tissues and reprogramming TAMs to M1like to kill tumors. Although these treatments have had some success, their effects are still limited. This paper mainly summarized the recruitment and polarization of macrophages by tumors, the support of TAMs for the growth of tumors, and the research progress of TAMs targeting tumors, to provide new treatment strategies for tumor immunotherapy.

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Section: Inhibition Of Tumor Angiogenesismentioning

confidence: 63%

The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy

2020

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“…STAT3 activation has been reported to show positive correlation with the proliferation and metastasis of tumor, and STAT1 enhances innate and adaptive immunity, triggering in most instances anti-proliferative and pro-apoptotic responses in tumor cells ( Avalle et al, 2012 ). Qing-Re-Huo-Xue (QRHX) formulae increases the expression of iNOS and decreases the expression of IL-6, TNF-α, and Arg-1 through the JAK2/STAT3 pathway, further reducing the numbers of TAMs and inhibiting tumor growth in lung cancer mouse model ( Xu et al, 2017 ) ( Figure 2 and Table 4 ). In the lung cancer mouse model, YPF also prolong the survival time of tumor mice through inhibiting the growth of lung cancer cells.…”

Section: The Impact Of Chm and Their Active Ingredients On Timps In Tmentioning

confidence: 99%

Impact of TCM on Tumor-Infiltrating Myeloid Precursors in the Tumor Microenvironment

Liu

Wang

Qiu

et al. 2021

Front. Cell Dev. Biol.

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The tumor microenvironment (TME) is composed of tumor cells, blood/lymphatic vessels, the tumor stroma, and tumor-infiltrating myeloid precursors (TIMPs) as a sophisticated pathological system to provide the survival environment for tumor cells and facilitate tumor metastasis. In TME, TIMPs, mainly including tumor-associated macrophage (TAM), tumor-associated dendritic cells (DCs), and myeloid-derived suppressor cells (MDSCs), play important roles in repressing the antitumor activity of T cell or other immune cells. Therefore, targeting those cells would be one novel efficient method to retard cancer progression. Numerous studies have shown that traditional Chinese medicine (TCM) has made extensive research in tumor immunotherapy. In the review, we demonstrate that Chinese herbal medicine (CHM) and its components induce tumor cell apoptosis, directly inhibiting tumor growth and invasion. Further, we discuss that TCM regulates TME to promote effective antitumor immune response, downregulates the numbers and function of TAMs/MDSCs, and enhances the antigen presentation ability of mature DCs. We also review the therapeutic effects of TCM herbs and their ingredients on TIMPs in TME and systemically analyze the regulatory mechanisms of TCM on those cells to have a deeper understanding of TCM in tumor immunotherapy. Those investigations on TCM may provide novel ideas for cancer treatment.

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“…In addition, many TCMs, such as berberine and G-Rh2, have the same effect as QRHX on tumor cells, but whether the mechanism of TCM is reversing the M2 phenotype to the M1 phenotype or blocking polarization into the M2 phenotype while promoting M1 polarization remains unclear. 107…”

Section: Effect Of Tcm Treatment On M1-tamsmentioning

confidence: 99%

<p>Effect and Molecular Mechanisms of Traditional Chinese Medicine on Tumor Targeting Tumor-Associated Macrophages</p>

He¹,

Yin²,

Xu³

2020

DDDT

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Traditional Chinese medicine (TCM) has been used as a significant cancer treatment method for many years in China. It has been demonstrated that TCM could assist in inhibiting the growth of tumors and prolonging the survival rates of cancer patients. Although the mechanism of TCM are still not clear, accumulating evidence has shown that they may be related to the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) play a significant role in TME and are polarized to two phenotypes, M1 (classically activated) and M2 (alternatively activated) TAMs. The two different phenotypes of TAMs play converse roles in the TME and M2-polarized tumor-associated macrophages (M2-TAMs) always lead to poor prognosis in cancer patients compared to M1-polarized tumorassociated macrophages (M1-TAMs). In this review, the potential correlation between TCM and TAMs (especially the M2 phenotype) in tumor progression and promising TCM strategies targeting TAMs in cancer are discussed.

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Targeting Tumor Microenvironment: Effects of Chinese Herbal Formulae on Macrophage‐Mediated Lung Cancer in Mice

Cited by 17 publications

References 43 publications

The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy

The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy

Impact of TCM on Tumor-Infiltrating Myeloid Precursors in the Tumor Microenvironment

<p>Effect and Molecular Mechanisms of Traditional Chinese Medicine on Tumor Targeting Tumor-Associated Macrophages</p>

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