Targeting VEGF/VEGFRs Pathway in the Antiangiogenic Treatment of Human Cancers by Traditional Chinese Medicine

Zhang, Cheng; Wang, Ning; Tan, Hor‐Yue; Guo, Wei; Li, Sha; Feng, Yibin

doi:10.1177/1534735418775828

Cited by 22 publications

(10 citation statements)

References 190 publications

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“…57 However, VEGF alone is not sufficient to promote cell tumorigenicity, suggesting that additional angiogenic factors and cytokines (such as TGF-β, tumor necrosis factor-α [TNF-α], interleukin-6 [IL-6]) regulated in their expression also are critical for an effective tumor initiation. [58][59][60] Additionally, MSC-specific VEGF expression appears to be tightly regulated based on physiological need, and may represent a superior means of inducing therapeutic angiogenesis. 61,62 Therefore, MSCs labeled with iron oxide nanoparticles might be advantageous to repairing damaged tissues.…”

Section: Cytokine Release From Mscs Labeled With Iron Oxide Nanopartimentioning

confidence: 99%

Iron oxide nanoparticles promote the migration of mesenchymal stem cells to injury sites

Li¹,

Wei²,

Lv³

et al. 2019

IJN

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BackgroundDeveloping new methods to deliver cells to the injured tissue is a critical factor in translating cell therapeutics research into clinical use; therefore, there is a need for improved cell homing capabilities.Materials and methodsIn this study, we demonstrated the effects of labeling rat bone marrow-derived mesenchymal stem cells (MSCs) with fabricated polydopamine (PDA)-capped Fe3O4 (Fe3O4@PDA) superparticles employing preassembled Fe3O4 nanoparticles as the cores.ResultsWe found that the Fe3O4@PDA composite superparticles exhibited no adverse effects on MSC characteristics. Moreover, iron oxide nanoparticles increased the number of MSCs in the S-phase, their proliferation index and migration ability, and their secretion of vascular endothelial growth factor relative to unlabeled MSCs. Interestingly, nanoparticles not only promoted the expression of C-X-C chemokine receptor 4 but also increased the expression of the migration-related proteins c-Met and C-C motif chemokine receptor 1, which has not been reported previously. Furthermore, the MSC-loaded nanoparticles exhibited improved homing and anti-inflammatory abilities in the absence of external magnetic fields in vivo.ConclusionThese results indicated that iron oxide nanoparticles rendered MSCs more favorable for use in injury treatment with no negative effects on MSC properties, suggesting their potential clinical efficacy.

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Section: Cytokine Release From Mscs Labeled With Iron Oxide Nanopartimentioning

confidence: 99%

Iron oxide nanoparticles promote the migration of mesenchymal stem cells to injury sites

Li¹,

Wei²,

Lv³

et al. 2019

IJN

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“…Therefore, the development of relevant inhibitors has great significance in anti-angiogenesis. Recent years, a number of studies have shown that Traditional Chinese Medicine can regulate VEGF in multi-targets and multi-pathways ( Qin et al, 2018 ; Zhang et al, 2018a ). Studies have found that the proliferation of vascular endothelial cells was significantly inhibited by leech and cantharides through reducing the expression of VEGF and matrix metalloproteinase 9 (MMP-9) ( Yao et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

A Systematic Study of Mechanism of Sargentodoxa cuneata and Patrinia scabiosifolia Against Pelvic Inflammatory Disease With Dampness-Heat Stasis Syndrome via Network Pharmacology Approach

Chen

et al. 2020

Front. Pharmacol.

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Objective: To investigate the mechanism of Sargentodoxa cuneata (Oliv.) Rehder & E.H.Wilson (SC) and Patrinia scabiosifolia (PS) against Pelvic Inflammatory Disease with Dampness-Heat Stasis Syndrome via network pharmacological approach and experimental validation.Methods: The active compounds with OB ≥ 30% and DL ≥ 0.18 were obtained from TCMSP database and further confirmed by literature research. The targets of the compounds and disease were acquired from multiple databases, such as GeneCards, CTD and TCMSP database. The intersection targets were identified by Venny software. Cytoscape 3.7.0 was employed to construct the protein-protein interaction (PPI) network and compound-target network. Moreover, GO enrichment and KEGG pathway analysis were analyzed by DAVID database. Finally, CCK-8, Griess assay and a cytometric bead array (CBA) immunoassay were used for experimental validation by detecting the influence of the active compounds on proliferation of macrophage, release of NO and TNF-α after LPS treatment.Results: 9 bioactive compounds were identified from SC and PS. Those compounds corresponded to 134 targets of pelvic inflammatory disease with dampness-heat stasis syndrome. The targets include vascular endothelial growth factor A (VEGFA), von willebrand factor (VWF), interleukin 6 (IL6), tumor necrosis factor (TNF) and nuclear transcription factor 1 (NFκB1). They act on the signaling pathways like advanced glycation end products-receptor of advanced glycation end products (AGE-RAGE), focal adhesion (FA), Toll-like receptor (TLR) and nuclear transcription factor κB (NF-κB). In addition, by in vitro validation, the selected active components of SC and PS such as acacetin, kaempferol, linarin, isovitexin, sinoacutine could significantly inhibit the release of NO induced by LPS, respectively. Moreover, different dose of acacetin, kaempferol, isovitexin and sinoacutine significantly inhibits the TNF-α production.Conclusion: This study provides solid evidence for the anti-inflammatory mechanism of SC and PS against pelvic inflammatory disease with dampness-heat stasis syndrome, which will provide a preliminary evidence and novelty ideas for future research on the two herbs.

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“…At present, studies on the anti-angiogenesis activities of monomer and Chinese herbal extracts are very transparent; however, basic research on compounds remains in its infancy. In the theory of TCM, formulae with multiple combinations of herbs are more frequently used for clinical therapy [ 182 ]. The complexity of alternative and complementary medicines makes it extremely difficult to systematically explain molecular mechanisms adequately using routine methodology [ 183 ].…”

Section: Discussionmentioning

confidence: 99%

Anti‐Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms

Zheng

Cao²,

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Endometriosis is caused by the growth or infiltration of endometrial tissues outside of the endometrium and myometrium. Symptoms include pain and infertility. Surgery and hormonal therapy are widely used in Western medicine for the treatment of endometriosis; however, the side effects associated with this practice include disease recurrence and menopause, which can severely influence quality of life. Angiogenesis is the main biological mechanism underlying the development of endometriosis. Numerous natural products and Chinese medicines with potent anti-angiogenic effects have been investigated, and the molecular basis underlying their therapeutic effects in endometriosis has been explored. This review aims to describe natural products and compounds that suppress angiogenesis associated with endometriosis and to assess their diverse molecular mechanisms of action. Furthermore, this review provides a source of information relating to alternative and complementary therapeutic products that mediate anti-angiogenesis. An extensive review of the literature and electronic databases, such as the China National Knowledge Infrastructure, PubMed, and Embase, was conducted using the keywords ‘endometriosis,' ‘traditional Chinese medicine,' ‘Chinese herbal medicine,' ‘natural compounds,' and ‘anti-angiogenic' therapy. Anti-angiogenic therapy is an emerging strategy for the treatment of endometriosis. Natural anti-angiogenic products and Chinese medicines provide several beneficial clinical effects, including pain relief. In this review, we summarize clinical trials and experimental studies of endometriosis using natural products and Chinese medicines. In particular, we focus on anti-angiogenic products and alternative and complementary medicines for the treatment of endometriosis and additionally examine their therapeutic efficacy and mechanisms of action. Anti-angiogenic natural products and/or compounds provide a new approach for the treatment of endometriosis. Future work will require randomized trials with larger numbers of subjects, as well as long-term follow-up to confirm the findings described here.

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Targeting VEGF/VEGFRs Pathway in the Antiangiogenic Treatment of Human Cancers by Traditional Chinese Medicine

Cited by 22 publications

References 190 publications

Iron oxide nanoparticles promote the migration of mesenchymal stem cells to injury sites

Iron oxide nanoparticles promote the migration of mesenchymal stem cells to injury sites

A Systematic Study of Mechanism of Sargentodoxa cuneata and Patrinia scabiosifolia Against Pelvic Inflammatory Disease With Dampness-Heat Stasis Syndrome via Network Pharmacology Approach

Anti‐Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms

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