Targetoid hemosiderotic hemangiomas (hobnail hemangiomas) are vascular lymphatic malformations: A study of 12 pediatric cases

Microvenular hemangioma: a clinicopathologic review of 13 cases

“…At least one author proposes that these vascular proliferations are best considered lymphatic malformations based on this immunophenotype. 20 Acquired tufted angioma is thought to be related to the morphologically and clinically similar kaposiform hemangioendothelioma. 21 Although microvenular hemangioma can have focal areas in the deep aspects resembling acquired tufted angioma, it lacks the distinctive nodular growth pattern.…”

Spitz Nevus Intermingling With a Hemangioma

“…In spite of the many features of the vascular component that were reminiscent of a hobnail hemangioma (such as the architectural pattern and the cytologic protruding endothelia), the vessels failed to express D2-40 (which is usually expressed by hobnail hemangioma). 14,15 Our case also included a SMA-positive continuous layer of pericytes, that is not found in hobnail hemangioma. 16 Such immunohistochemical pattern also rules out a lymphatic reactive lesion or malformation such as lymphangiectasies accompanying the melanocytic nevus.…”

A Red-violaceous Papular Lesion in a Young Girl: A Quiz

“…Influences of sex steroid hormones have been proposed but immunohistochemical staining failed to demonstrate either oestrogen or progesterone receptors (5). A lymphatic origin has also been hypothesised and supported by lymphatic endothelial cell marker D2-40 positivity and general lack of CD34 staining (6,7).…”

“…In the superficial and mid-dermis, a single layer of endothelial cells (positive for CD31), with hobnail appearance (scanty cytoplasm and rounded nuclei protruding into the lumen), lines the ectatic and dilated vascular lumens; in the deeper dermis, the vascular spaces are narrower and angulated and often appear to dissect through collagen bundles. Moreover, a scattered haemosiderin deposition may be seen in the dermis (7,8,10,11).…”