Task-Based Profile of Vocal Intensity Decline in Parkinson’s Disease

Rosen, Kristin M.; Kent, Raymond D.; Duffy, Joseph R.

doi:10.1159/000081959

Cited by 49 publications

(28 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since the recording of speech signals is noninvasive and can be readily integrated into telemedicine applications, such tests are good candidates in this regard. The use of sustained vowel phonations to assess the extent of vocal symptoms, where the patient is requested to hold the frequency of phonation steady for as long as possible, is common in general speech clinical practice [20] and in PD monitoring [21,22]. This circumvents some of the confounding articulatory effects and linguistic components of running speech [38], i.e.…”

Section: Introductionmentioning

confidence: 99%

Accurate Telemonitoring of Parkinson's Disease Progression by Noninvasive Speech Tests

Tsanas

Little

McSharry

et al. 2010

IEEE Trans. Biomed. Eng.

522

271

View full text Add to dashboard Cite

Abstract-Tracking Parkinson's disease (PD) symptom progression often uses the Unified Parkinson's DiseaseRating Scale (UPDRS), which requires the patient's presence in clinic, and time-consuming physical examinations by trained medical staff. Thus, symptom monitoring is costly and logistically inconvenient for patient and clinical staff alike, also hindering recruitment for future large-scale clinical trials. Here, for the first time, we demonstrate rapid, remote replication of UPDRS assessment with clinically useful accuracy (about 7.5 UPDRS points difference from the clinicians' estimates), using only simple, self-administered, and non-invasive speech tests. We characterize speech with signal processing algorithms, extracting clinically useful features of average PD progression. Subsequently, we select the most parsimonious model with a robust feature selection algorithm, and statistically map the selected subset of features to UPDRS using linear and nonlinear regression techniques, which include classical least squares and nonparametric classification and regression trees (CART). We verify our findings on the largest database of PD speech in existence (~6,000 recordings from 42 PD patients, recruited to a six-month, multi-centre trial). These findings support the feasibility of frequent, remote and accurate UPDRS tracking. This technology could play a key part in telemonitoring frameworks that enable large-scale clinical trials into novel PD treatments.

show abstract

Section: Introductionmentioning

confidence: 99%

Accurate Telemonitoring of Parkinson's Disease Progression by Noninvasive Speech Tests

Tsanas

Little

McSharry

et al. 2010

IEEE Trans. Biomed. Eng.

522

271

View full text Add to dashboard Cite

show abstract

“…DDK is also known as 'alternate clinical evaluation procedures has been considered an important means of advancing our understanding of communication disorders [8,12,14,15] .…”

Section: Introductionmentioning

confidence: 99%

“…The DDK test has been used in the assessment of children with several speech alterations [11] , as well as in adults with neurological diseases [12] and patients who were submitted to laryngeal vertical hemilaryngectomy [13] . DDK associated with other…”

mentioning

confidence: 99%

Oral and Vocal Fold Diadochokinesis in Children

Modolo

Berretin-Felix

Genaro

et al. 2010

Folia Phoniatr Logop

View full text Add to dashboard Cite

Aim: To establish reference values concerning the results of oral and vocal fold diadochokinesis (DDK) assessment, as well as to analyze the differences among gender and age. Methods: One hundred and fifty Brazilian-Portuguese-speaking children from 8 to 10 years old were assessed. The DDK was assessed through the repetition of ‘pa’, ‘ta’, ‘ka’, ‘pataka’, ‘a’ and ‘i’. Results: As age increased there was a rise in the average DDK rate, a rise in the coefficient of variation of period for syllable ‘ka’ and a rise in the coefficient of variation of the peak intensity for the syllable ‘ta’. The number of utterances per second of ‘ta’ was higher for girls than for boys. In trisyllables, 8-year-old girls presented a lower number of utterances than the other subgroups. As age increased, there was a rise in the average DDK rate of the vowel ‘i’ for girls; there was also a smaller standard deviation and perturbations of the period for this same vowel. Conclusion: Oral and vocal fold DDK reference values were established and differences as to gender and age were observed.

show abstract

“…DDK rate appears to be a useful index of oral motor development in children [10][11][12][13][14] . DDK has been used as a measure of the speech deterioration in amyotrophic lateral sclerosis [15][16][17] , cerebellar and spinocerebellar damage [8,[18][19][20][21][22] , Friedreich disease [23] , multiple sclerosis [24,25] , Parkinson's disease [25,26] , hemispheric stroke [20,27] , traumatic brain injury [28] , apraxia of speech [29] , and cerebellar mutism syndrome [30] . Slow rate, temporal and intensity irregularities, and inaccuracy in the DDK task are reported in a number of studies on speech impairment associated with a neurogenic disease or damage, including cerebral palsy, developmental dyspraxia, stroke, amyotrophic lateral sclerosis, cerebellar diseases, and basal ganglia disorders [19] .…”

mentioning

confidence: 99%

Analysis of Diadochokinesis in Ataxic Dysarthria Using the Motor Speech Profile Program™

Wang

Kent

Duffy³

et al. 2008

Folia Phoniatr Logop

Self Cite

View full text Add to dashboard Cite

Aims: The Diadochokinetic Rate Analysis (DRA) in the KayPENTAX Motor Speech Profile is a computer program for the analysis of diadochokinesis (DDK). The objective of this study is to evaluate the suitability, reliability, and concurrent validity of the results from the DRA protocol and hand measurement for individuals with ataxic dysarthria, which is characteristically associated with dysdiadochokinesis. Methods: Twenty-one participants with ataxic dysarthria were recorded as they repeated various syllables as quickly and steadily as possible. The DDK samples were executed by the DRA protocol at different thresholds and were also hand-measured. Analyses were based on the percentage of nonexecutable DDK samples, defined as samples in which the lowest peak intensity during CV syllables is lower than the highest peak intensity during intersyllable pauses, and the comparisons of the results between repeated analyses at different thresholds and between automatic and manual measuring methods. Results: (1) More than one third of the DDK samples were nonexecutable; (2) the reliability at different thresholds and concurrent validity between different measuring methods were both satisfactory, and (3) temporal variation parameters were more inconsistent between different measuring methods than intensity variation parameters. Conclusion: DRA has notable limitations in its clinical application but there is a considerable potential for improving its performance.

show abstract

Task-Based Profile of Vocal Intensity Decline in Parkinson’s Disease

Cited by 49 publications

References 32 publications

Accurate Telemonitoring of Parkinson's Disease Progression by Noninvasive Speech Tests

Accurate Telemonitoring of Parkinson's Disease Progression by Noninvasive Speech Tests

Oral and Vocal Fold Diadochokinesis in Children

Analysis of Diadochokinesis in Ataxic Dysarthria Using the Motor Speech Profile Program™

Contact Info

Product

Resources

About