2014
DOI: 10.1016/j.brs.2013.12.016
|View full text |Cite
|
Sign up to set email alerts
|

Task-dependent Activity and Connectivity Predict Episodic Memory Network-based Responses to Brain Stimulation in Healthy Aging

Abstract: Background Transcranial Magnetic Stimulation (TMS) can affect episodic memory, one of the main cognitive hallmarks of aging, but the mechanisms of action remain unclear. Objectives To evaluate the behavioral and functional impact of excitatory TMS in a group of healthy elders. Methods We applied a paradigm of repetitive TMS -intermittent theta-burst stimulation- over left inferior frontal gyrus in healthy elders (n=24) and evaluated its impact on the performance of an episodic memory task with two levels o… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

5
67
0
1

Year Published

2015
2015
2023
2023

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 70 publications
(73 citation statements)
references
References 91 publications
5
67
0
1
Order By: Relevance
“…Combined noninvasive brain stimulation and neuroimaging studies [61][62][63][64] may shed light on how functional interactions between remote but interconnected brain regions may mediate strengthening of existing memories in young and older adults. The tDCS technique involves the application of weak electrical currents directly to the head for several minutes and these currents generate an electrical field that modulates neuronal activity according to the modality of the application [65,66].…”
Section: Discussionmentioning
confidence: 99%
“…Combined noninvasive brain stimulation and neuroimaging studies [61][62][63][64] may shed light on how functional interactions between remote but interconnected brain regions may mediate strengthening of existing memories in young and older adults. The tDCS technique involves the application of weak electrical currents directly to the head for several minutes and these currents generate an electrical field that modulates neuronal activity according to the modality of the application [65,66].…”
Section: Discussionmentioning
confidence: 99%
“…Combined NIBS and neuroimaging studies (Censor et al, , 2014Macher et al, 2014;Vidal-Pineiro et al, 2014) may shed light on how functional interactions between remote but interconnected brain regions may mediate strengthening of existing memories in young and older adults.…”
Section: Discussionmentioning
confidence: 99%
“…Intermittent TBS (iTBS) tends to enhance cortical excitability, while continuous TBS (cTBS) usually produces inhibitory post-effects [23] both in the underlying stimulated tissue and in distal interconnected areas [26]. However NIBS after-effects are highly dependent on a variety of parameters [27] such as functional brain connectivity that mediates the neural and cognitive response to NIBS [26,28]. rTMS can directly modulate DMN expression [29,30] by targeting an accessible cortical node of this network; the left IPL.…”
Section: Introductionmentioning
confidence: 98%
“…Physiological and pharmacological investigations revealed glutamatergic [24] and GABAergic [25] involvement in TBS-induced plasticity effects. Intermittent TBS (iTBS) tends to enhance cortical excitability, while continuous TBS (cTBS) usually produces inhibitory post-effects [23] both in the underlying stimulated tissue and in distal interconnected areas [26]. However NIBS after-effects are highly dependent on a variety of parameters [27] such as functional brain connectivity that mediates the neural and cognitive response to NIBS [26,28].…”
Section: Introductionmentioning
confidence: 99%